Systems and methods for providing an intelligent network to onboard patients to specialty medications are described herein. A server system for enrolling patients into a patient engagement service may be configured to receive an electronic indication of a trigger event message, the trigger event message associated with a patient identified with patient context data, a therapy for the patient identified with a therapy identifier, and a sponsor of the therapy identified with a sponsor identifier; determine, based on the sponsor identifier, the patient context data, and the therapy identifier, whether the patient engagement service is available and supported for the sponsor; and initiate the patient engagement service.