Provided are a configuration method, apparatus, system and device for a data flow, and a computer medium. The configuration method for a data flow includes: when the first network element needs to offload part of QFs in a PDU Session to a second network element for transmission, a request message is sent to the second network element, where the request message carries an uplink interface address on a core network side; the second network element receives the request message sent by the first network element, and obtains, according to the request message, the uplink interface address on the core network side required for a QF offloaded to the second network element.