Provided are a method for creating a cell mathematical model capable of evaluating characteristics of cells from experimental data, a program, and a creation apparatus. Also provided are a method for determining the created cell mathematical model, a program, and a determination apparatus. The method for creating a mathematical model receives culture data of the cells, extracts feature values of cell activity from the culture data, creates a cell mathematical model from the feature values, and outputs the cell mathematical model. The method for determining the created cell mathematical model determines that estimated culture data calculated using the cell mathematical model reflects the culture data.