公开(公告)号：US20240321391A1

公开(公告)日：2024-09-26

申请号：US18734587

申请日：2024-06-05

申请人： Cyclica Inc.

发明人： Stephen Scott MACKINNON ,  Leonard David MORAYNISS ,  Jason MITAKIDIS ,  Fuad G GWADRY

IPC分类号： G16B20/30 ,  G16B5/00 ,  G16B15/00 ,  G16B15/30 ,  G16B20/00 ,  G16B35/00 ,  G16B35/20 ,  G16B50/00 ,  G16B50/10 ,  G16B50/30 ,  G16B99/00 ,  G16C20/60

CPC分类号： G16B20/30 ,  G16B5/00 ,  G16B15/00 ,  G16B15/30 ,  G16B20/00 ,  G16B35/00 ,  G16B35/20 ,  G16B50/00 ,  G16B50/10 ,  G16B50/30 ,  G16B99/00 ,  G16C20/60

摘要： The invention involves a method for identifying a target protein. The invention involves receiving a request to identify a target protein based on a ligand; identifying, using the ligand, a first protein, where the ligand binds with the first protein to fonn a ligand-protein complex; generating, a first binding site profile for the first protein, where the first binding site profile describes molecular properties of the first protein; obtaining, from a controlled server, structure data describing molecular properties of surfaces for a multitude of proteins, where the multitude of proteins comprises the target protein; identifying, using the first binding site profile and the structure data, the target protein; and presenting the target protein to a user.

公开(公告)号：US12100485B2

公开(公告)日：2024-09-24

申请号：US16293607

申请日：2019-03-05

申请人： The Board of Trustees of the Leland Stanford Junior University

发明人： Evan Nathaniel Feinberg ,  Vijay Satyanand Pande

IPC分类号： G16B5/00 ,  G06F30/20 ,  G06F111/08 ,  G06N20/20

CPC分类号： G16B5/00 ,  G06F30/20 ,  G06N20/20 ,  G06F2111/08

摘要： Systems and methods for molecular simulation in accordance with embodiments of the invention are illustrated. One embodiment includes a method for predicting a relationship between a ligand and a receptor. The method includes steps for identifying a plurality of conformations of a receptor, computing docking scores for each of the plurality of conformations and a set of one or more ligands, and predicting a relationship between the set of one or more ligands and the plurality of conformations of the receptor.

公开(公告)号：US12100482B2

公开(公告)日：2024-09-24

申请号：US18503392

申请日：2023-11-07

申请人： GUARDANT HEALTH, INC.

发明人： Darya Chudova ,  Helmy Eltoukhy ,  Stefanie Ann Ward Mortimer ,  Diana Abdueva

IPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30

CPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30 ,  C12Q2535/122 ,  C12Q2537/159

摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

公开(公告)号：US12094575B2

公开(公告)日：2024-09-17

申请号：US18515039

申请日：2023-11-20

申请人： Venn Biosciences Corporation

发明人： Daniel Serie ,  Zhenqin Wu

IPC分类号： G16B40/00 ,  G16B5/00

CPC分类号： G16B40/00 ,  G16B5/00

摘要： A system and method for automated detection of the presence or absence of a quantity based on intensities expressed in terms of, or derived from frequency or time dependent data. According to one example intensities from mass spectrometry are identified using a non-linear mathematical model, such as an artificial neural network trained to find start and stop peaks of an intensity, from which an abundance may be determined.

公开(公告)号：US12094573B2

公开(公告)日：2024-09-17

申请号：US18506734

申请日：2023-11-10

申请人： GUARDANT HEALTH, INC.

发明人： Darya Chudova ,  Helmy Eltoukhy ,  Stefanie Ann Ward Mortimer ,  Diana Abdueva

IPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30

CPC分类号： G16B30/00 ,  C12Q1/6806 ,  C12Q1/6827 ,  G16B5/00 ,  G16B25/10 ,  G16B40/30 ,  C12Q2535/122 ,  C12Q2537/159

摘要： The present disclosure provides a method for enriching for multiple genomic regions using a first bait set that selectively hybridizes to a first set of genomic regions of a nucleic acid sample and a second bait set that selectively hybridizes to a second set of genomic regions of the nucleic acid sample. These bait set panels can selectively enrich for one or more nucleosome-associated regions of a genome, said nucleosome-associated regions comprising genomic regions having one or more genomic base positions with differential nucleosomal occupancy, wherein the differential nucleosomal occupancy is characteristic of a cell or tissue type of origin or disease state.

公开(公告)号：US20240301511A1

公开(公告)日：2024-09-12

申请号：US18220800

申请日：2023-07-11

申请人： Anhui Agricultural University

发明人： Guomin HAN ,  Qi LIU ,  Chuangchuang XU ,  Shunli HU

IPC分类号： C12Q1/689 ,  G16B5/00 ,  G16B20/00 ,  G16B25/10 ,  G16B40/20

CPC分类号： C12Q1/689 ,  G16B5/00 ,  G16B20/00 ,  G16B25/10 ,  G16B40/20

摘要： The present application relates to a method, apparatus, device and medium for identifying candidate genes that regulate the shape of bacteria. The method includes: obtaining reference genome data of bacteria and performing protein domain analysis on the reference genome data of bacteria; determining the feature value dataset for each bacterium based on the structural domains of all proteins obtained from the analysis; obtaining shape information of each bacterium; training a bacterial shape prediction model based on the shape information of each bacterium and the feature value dataset, and determining the weights of each protein domain in influencing the shape of the bacterium according to the bacterial prediction model; determining candidate genes that regulate the shape of bacteria based on the weights. This method can be used to rapidly screen out the candidate genes that regulate the shape of bacteria, and establish a new method for mining biofunctional genes.

公开(公告)号：US12087404B2

公开(公告)日：2024-09-10

申请号：US17892701

申请日：2022-08-22

申请人： Peptilogics, Inc.

发明人： Francis Lee ,  Jonathan D. Steckbeck ,  Hannes Holste

IPC分类号： G16B40/00 ,  G06F3/14 ,  G06F9/451 ,  G06F16/242 ,  G06F16/248 ,  G06F16/29 ,  G06N20/00 ,  G16B5/00 ,  G16B10/00 ,  G16B30/00 ,  G16B35/00 ,  G16B45/00 ,  G16C20/70 ,  G16H10/20 ,  G16H50/20 ,  G16H50/70 ,  G16H70/40 ,  G06Q30/0201 ,  G06Q50/04 ,  G06Q50/18 ,  G16H40/20

CPC分类号： G16B40/00 ,  G06F3/14 ,  G06F9/451 ,  G06F16/2428 ,  G06F16/248 ,  G06F16/29 ,  G06N20/00 ,  G16B5/00 ,  G16B10/00 ,  G16B30/00 ,  G16B35/00 ,  G16B45/00 ,  G16C20/70 ,  G16H10/20 ,  G16H50/20 ,  G16H50/70 ,  G16H70/40 ,  G06Q30/0201 ,  G06Q50/04 ,  G06Q50/184 ,  G16H40/20

摘要： In one aspect, a method includes generating a design space for a peptide for an application. The generating includes identifying sequences for the peptide, and updating the sequences by determining, for each of the sequences, a respective set of activities pertaining to the application. The updating produces updated sequences each having updated respective activities. The method includes generating, based on the updated sequences, a solution space within the design space. The solution space includes a target subset of the updated sequences. The method includes performing, using a machine learning model to process the solution space, trials to identify a candidate drug compound that represents a sequence having a level of activity that exceeds a threshold level, and determining metrics pertaining to the machine learning model and a second machine learning model that performs the trials.

公开(公告)号：US12068059B2

公开(公告)日：2024-08-20

申请号：US16481061

申请日：2018-01-25

申请人： Whitehead Institute for Biomedical Research ,  Massachusetts Institute of Technology

发明人： Vikram Khurana ,  Chee Yeun Chung ,  Susan Lindquist ,  Bonnie A. Berger ,  Ernest Fraenkel ,  Jian Peng

IPC分类号： G01N33/48 ,  C12Q1/02 ,  G01N33/50 ,  G16B5/00 ,  G16B25/00 ,  G16B30/10

CPC分类号： G16B5/00 ,  C12Q1/025 ,  G01N33/5058 ,  G16B25/00 ,  G16B30/10 ,  G01N2500/10

摘要： Disclosed are methods, systems, cells and compositions directed to modeling a physiologic or pathologic process in an animal using a set of yeast genes analogous to a set of animal genes and augmenting the physiologic or pathologic process in the animal with predicted gene interactions based on the interactions between the set of yeast genes. Also disclosed are methods of screening for and using therapeutics for neurodegenerative proteinopathies.

公开(公告)号：US20240265993A1

公开(公告)日：2024-08-08

申请号：US18018858

申请日：2022-01-04

申请人： BOE Technology Group Co., Ltd.

发明人： Zhenzhong ZHANG

IPC分类号： G16B5/00 ,  G06N3/08 ,  G16B40/20

CPC分类号： G16B5/00 ,  G06N3/08 ,  G16B40/20

摘要： A method for training a vector model, including: obtaining more than one RNA sequence and more than one protein sequence; obtaining more than one first RNA vector by vectorizing the more than one RNA sequence; obtaining more than one first protein vector by vectorizing the more than one protein sequence; determining an interaction between the RNA sequence and the protein sequence according to the first RNA vector and the first protein vector; obtaining a similarity of more than one RNA-RNA pair by calculating a distance between any two RNA sequences; obtaining a similarity of more than one protein-protein pair by calculating a distance between any two protein sequences; training the vector model according to an interaction between the RNA sequence and the protein sequence, the similarity of the RNA-RNA pair and the similarity of the protein-protein pair.

公开(公告)号：US20240238619A1

公开(公告)日：2024-07-18

申请号：US18563860

申请日：2022-05-26

申请人： The Regents of the University of California ,  The Salk Institute for Biological Studies

发明人： Aditya Vasan ,  James Friend ,  Jeremy Orosco ,  Sreekanth Chalasani ,  Uri Magaram

IPC分类号： A61N7/00 ,  B06B1/06 ,  G16B5/00 ,  G16H20/30 ,  G16H40/67

CPC分类号： A61N7/00 ,  B06B1/0644 ,  G16B5/00 ,  G16H20/30 ,  G16H40/67 ,  B06B2201/76

摘要： A system of ultrasound based cellular stimulation may include a stimulation apparatus and a stimulation controller. The stimulation apparatus may include a transducer element formed from a single crystal piezoelectric material such as lithium niobate. The stimulation apparatus may deliver high magnitudes of acoustic pressure relative to its dimensions (e.g., size, weight, and/or the like) and without significant heating. The stimulation controller may determine a cellular response to ultrasound stimulation such as membrane deflection and transmembrane voltage change. The stimulation controller may determine, based on the predicted cellular response, parameters for an ultrasound stimulation treatment for a patient such as a magnitude and/or duration of an ultrasonic stimulus for achieving a desired magnitude of membrane deflection and/or transmembrane voltage changes. The ultrasound stimulation treatment may be administered to the patient by the stimulation apparatus operating in accordance with the parameters.