An example method includes receiving data that includes a set of spectral metrics from interactions of electromagnetic radiation with a sample. A first trained model and a second trained model is applied to at least one of the set of spectral metrics and a set of values based on the set of spectral metrics to obtain a first result and a second result. Based on at least one of the first result and the second result, either a positive particle of interest detection or a negative particle of interest detection for at least one of first particles of interest, a first type of the first particles of interest, and a second type of the first particles of interest for the sample is determined. A particle of interest detection notification that indicates either the positive particle of interest detection or the negative particle of interest detection is generated and provided.