发明公开
- 专利标题： PURIFICATION OF ANTIBODY DRUG CONJUGATES USING A SODIUM PHOSPHATE GRADIENT
-
申请号： US18322395申请日： 2023-05-23
-
公开(公告)号： US20240150394A1公开(公告)日： 2024-05-09
- 发明人: Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang
- 申请人： PFIZER INC.
- 申请人地址： US NY New York
- 专利权人： PFIZER INC.
- 当前专利权人： PFIZER INC.
- 当前专利权人地址： US NY New York
- 主分类号： C07K1/18
- IPC分类号： C07K1/18 ; A61K47/68
摘要：
Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.
信息查询
