专利检索 ap:("PFIZER INC.") AND inv:"Durgesh V. Nadkarni" 第 1 页

1.

发明公开
PURIFICATION OF ANTIBODY DRUG CONJUGATES USING A SODIUM PHOSPHATE GRADIENT 审中-公开

公开(公告)号：US20240150394A1

公开(公告)日：2024-05-09

申请号：US18322395

申请日：2023-05-23

申请人： PFIZER INC.

发明人： Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang

IPC分类号： C07K1/18 , A61K47/68

CPC分类号： C07K1/18 , A61K47/6811 , A61K47/6849

摘要： Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.

2.

发明授权
Purification of antibody drug conjugates using a sodium phosphate gradient 有权

公开(公告)号：US11661438B2

公开(公告)日：2023-05-30

申请号：US15778290

申请日：2016-12-07

申请人： PFIZER INC.

发明人： Durgesh V. Nadkarni , Jeffry R. Borgmeyer , He Meng , Qingping Jiang

IPC分类号： C07K1/18 , C07K1/22 , A61K47/68

CPC分类号： C07K1/18 , A61K47/6811 , A61K47/6849

摘要： Methods of removing high molecular weight species, in particular aggregates, from antibody drug conjugate preparations, by contacting preparations of the antibody drug conjugate reaction mixture with a hydroxyapatite resin and selectively eluting the ADC from the resin using a gradient comprising sodium phosphate.