Invention Publication
- Patent Title: PREVENTION OF DISULFIDE BOND REDUCTION DURING RECOMBINANT PRODUCTION OF POLYPEPTIDES
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Application No.: US18410876Application Date: 2024-01-11
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Publication No.: US20240150486A1Publication Date: 2024-05-09
- Inventor: Yung-Hsiang KAO , Michael W. LAIRD , Melody Trexler SCHMIDT , Rita L. WONG , Daniel P. HEWITT
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- The original application number of the division: US18194471 2023.03.31
- Main IPC: C07K16/28
- IPC: C07K16/28 ; A61K39/395 ; C07K1/14
Abstract:
The invention concerns methods and means for preventing the reduction of disulfide bonds during the recombinant production of disulfide-containing polypeptides. In particular, the invention concerns the prevention of disulfide bond reduction during harvesting of disulfide-containing polypeptides, including antibodies, from recombinant host cell cultures.
Public/Granted literature
- US11987637B1 Prevention of disulfide bond reduction during recombinant production of polypeptides Public/Granted day:2024-05-21
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