Invention Publication
- Patent Title: MODIFIED SELF-IMMOLATING MOIETIES FOR USE IN PRODRUGS AND CONJUGATES AND METHODS OF USING AND MAKING
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Application No.: US18413928Application Date: 2024-01-16
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Publication No.: US20240165249A1Publication Date: 2024-05-23
- Inventor: Yam B. POUDEL , Sanjeev GANGWAR
- Applicant: BRISTOL-MYERS SQUIBB COMPANY
- Applicant Address: US NJ Princeton
- Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee: BRISTOL-MYERS SQUIBB COMPANY
- Current Assignee Address: US NJ Princeton
- Main IPC: A61K47/65
- IPC: A61K47/65 ; A61K45/06 ; A61K47/64 ; A61K47/68 ; A61P35/00
Abstract:
Methods of making compounds represented by formula (I)
can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.
can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.
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