公开(公告)号：US20230348468A1

公开(公告)日：2023-11-02

申请号：US17793278

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Matthew COX ,  Naidu S. CHOWDARI ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Christine M. TARBY ,  Yam B. POUDEL ,  Murugaiah ANDAPPAN MURUGAIAH SUBBAIAH

IPC: C07D487/04 ,  C07K16/28

CPC classification number: C07D487/04 ,  C07K16/2818 ,  C07K16/2827

Abstract: Compounds according to formula I or II are useful as agonists of Toll-like receptor 7 (TLR7). (I) (II) Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230118688A1

公开(公告)日：2023-04-20

申请号：US17792869

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Heng CHENG ,  Christine M. TARBY ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Walter L. JOHNSON ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Patrice GILL ,  Andrew F. DONNELL ,  Murugaiah Andappan Murugaiah SUBBAIAH

IPC: A61K31/519 ,  C07D487/04 ,  A61K39/395

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20210053979A1

公开(公告)日：2021-02-25

申请号：US17043886

申请日：2019-04-23

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Ashok V. PURANDARE ,  Honghe WAN ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM ,  Naidu S. CHOWDARI

IPC: C07D487/16 ,  A61K47/60

Abstract: Compounds having a structure according to formula are modulators of TLR7 activity and can be used to treat conditions amenable to treatment by the modulation of TLR7 activity.

公开(公告)号：US20200095248A1

公开(公告)日：2020-03-26

申请号：US16676870

申请日：2019-11-07

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Liqi HE ,  Sanjeev GANGWAR ,  Yam B. POUDEL ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61P37/04

Abstract: Compounds having a structure according to formula (I) or (II) where R1, R2, R3, R4, Ar and X1 are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20200038403A1

公开(公告)日：2020-02-06

申请号：US16527802

申请日：2019-07-31

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR ,  Liqi HE ,  Prasanna SIVAPRAKASAM ,  Matthias BROEKEMA ,  Matthew COX ,  Christine M. TARBY ,  Qian ZHANG

IPC: A61K31/519 ,  C07D487/04 ,  A61K39/395 ,  A61K47/60

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230140430A1

公开(公告)日：2023-05-04

申请号：US17792887

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Matthew COX ,  Liqi HE ,  Sanjeev GANGWAR ,  Ashvinikumar V. GAVAI ,  Matthias BROEKEMA ,  Qiang CONG ,  Daniel O'MALLEY ,  Yam B. POUDEL ,  Christine M. TARBY

IPC: C07D519/00 ,  A61K45/06

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20230127326A1

公开(公告)日：2023-04-27

申请号：US17792905

申请日：2021-01-26

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Christine M. TARBY ,  Qiang CONG ,  Ashvinikumar V. GAVAI ,  Sanjeev GANGWAR ,  Matthias BROEKEMA ,  Patrice GILL ,  Prasanna SIVAPRAKASAM ,  Walter L. JOHNSON ,  Murugaiah Andappan Murugaiah SUBBAIAH ,  Yam B. POUDEL

IPC: A61K31/519 ,  A61K39/395 ,  C07D487/04

Abstract: Compounds according to formula I are useful as agonists of Toll-like receptor 7 (TLR7). Such compounds can be used in cancer treatment, especially in combination with an anti-cancer immunotherapy agent, or as a vaccine adjuvant.

公开(公告)号：US20210113706A1

公开(公告)日：2021-04-22

申请号：US17126555

申请日：2020-12-18

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Sanjeev GANGWAR

IPC: A61K47/65 ,  A61K47/64 ,  A61K47/68 ,  A61P35/00 ,  A61K45/06

Abstract: Compounds represented by formula (I) can be used to make antibody-drug conjugates. The conjugates so made are stable in both human and mouse serum, enabling the performance of pre-clinical studies using a mouse model.

公开(公告)号：US20200308175A1

公开(公告)日：2020-10-01

申请号：US16902860

申请日：2020-06-16

Applicant: BRISTOL-MYERS SQUIBB COMPANY

Inventor： Yam B. POUDEL ,  Liqi HE ,  Sanjeev GANGWAR ,  Shoshana L. POSY ,  Prasanna SIVAPRAKASAM

IPC: C07D473/18 ,  A61K47/68 ,  A61P37/04 ,  A61K47/60

Abstract: Compounds having a structure according to formula (I) where R1 and Ar are as defined herein, are agonists for the Toll-like receptor 7 (TLR7) and can be used as adjuvants for stimulating the immune system. Some such compounds can be used in conjugates for targeted delivery to the organ or tissue of intended action.

公开(公告)号：US20190382412A1

公开(公告)日：2019-12-19

申请号：US16357109

申请日：2019-03-18

Applicant: WILLIAM MARSH RICE UNIVERSITY ,  BRISTOL-MYERS SQUIBB COMPANY ,  THE SCRIPPS RESEARCH INSTITUTE

Inventor： Kyriacos C. Nicolaou ,  Min LU ,  Debashis MANDAL ,  Sanjeev GANGWAR ,  Naidu S. CHOWDARI ,  Yam B. POUDEL

IPC: C07D491/08 ,  A61K47/68

Abstract: In one aspect, the present disclosure provides new analogs of uncialamycin. The present disclosure also provides novel synthetic pathways to obtaining uncialamycin and analogs thereof. Additionally, the present disclosure also describes methods of use of uncialamycin and analogs thereof. In another aspect, the present disclosure provides antibody-drug conjugates which may be used to treat cancer or another disease or disorder.