An appliance cabinet includes an outer wrapper that encloses an inner liner. The outer wrapper defines an integrally formed machine compartment. A vacuum insulated structure is defined between the outer wrapper and the inner liner. A selectively removable side access panel is removably coupled to the outer wrapper. The selectively removable side access panel includes a central body with support ribs and an arcuate offset flange that extends orthogonally from the central body. Vertical supports are operably coupled to the top and the bottom of a frame and define at least one retention slot. The selectively removable side access panel includes at least one retention tab selectively disposed within the at least one retention slot.