发明公开
- 专利标题: SULFONAMIDE SUBSTITUTED N-(1H-INDOL-7-YL)BENZENESULFONAMIDES AND USES THEREOF
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申请号: US18275382申请日: 2022-02-01
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公开(公告)号: US20240190821A1公开(公告)日: 2024-06-13
- 发明人: William J. Greenlee , Nicholas Calandra , Soumya Ray , Arthur F. Kluge
- 申请人: Triana Biomedicines, Inc.
- 申请人地址: US MA Lexington
- 专利权人: Triana Biomedicines, Inc.
- 当前专利权人: Triana Biomedicines, Inc.
- 当前专利权人地址: US MA Lexington
- 国际申请: PCT/US2022/014723 2022.02.01
- 进入国家日期: 2023-08-01
- 主分类号: C07D209/40
- IPC分类号: C07D209/40 ; C07D401/12 ; C07D403/12 ; C07D405/12 ; C07D471/04 ; C07D471/18 ; C07D487/04 ; C07D487/10 ; C07D498/10
摘要:
The present application discloses novel compounds of formula (I), pharmaceutical compositions containing these compounds and methods of inducing degradation of a protein, comprising contacting the protein with an effective amount of a compound of the disclosure. Methods of treating disease and disorders that results from abnormal activity of a target protein in a subject, are also disclosed.
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