- 专利标题： 5,7-DIHYDRO-PYRROLO-PYRIDINE DERIVATIVES
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申请号： US18532547申请日： 2023-12-07
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公开(公告)号： US20240190869A1公开(公告)日： 2024-06-13
- 发明人: Lei Zhang , Christopher Ryan Butler , Elizabeth Mary Beck , Michael Aaron Brodney , Matthew Frank Brown , Laura Ann McAllister , Erik Alphie LaChapelle , Adam Matthew Gilbert
- 申请人： Pfizer Inc.
- 申请人地址： US NY New York
- 专利权人： Pfizer Inc.
- 当前专利权人： Pfizer Inc.
- 当前专利权人地址： US NY New York
- 分案原申请号： US15637071 2017.06.29
- 主分类号： C07D471/04
- IPC分类号： C07D471/04 ; A61K31/437 ; A61P25/00 ; A61P25/16 ; A61P25/18 ; A61P25/28
摘要：
The present invention provides, in part, compounds of Formula I:
or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
or an N-oxide thereof, or a pharmaceutically acceptable salt of the compound or the N-oxide, wherein: R1, R2, L, A, and E are as described herein; processes for the preparation of; intermediates used in the preparation of; and compositions containing such compounds, N-oxides, or salts, and their uses for treating M4-mediated (or M4-associated) disorders including, e.g., Alzheimer's Disease, schizophrenia (e.g., its cognitive and negative symptoms), pain, addiction, and a sleep disorder.
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