- 专利标题： RECOMBINANT CHIMERIC BOVINE/HUMAN PARAINFLUENZA VIRUS 3 EXPRESSING SARS-COV-2 SPIKE PROTEIN AND ITS USE
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申请号： US18555137申请日： 2022-04-27
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公开(公告)号： US20240197861A1公开(公告)日： 2024-06-20
- 发明人: Ursula J. Buchholz , Shirin Munir , Cyril Le Nouen , Xueqiao Liu , Cindy Luongo , Peter L. Collins
- 申请人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 申请人地址： US MD Bethesda
- 专利权人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 当前专利权人： The U.S.A., as represented by the Secretary, Department of Health and Human Services
- 当前专利权人地址： US MD Bethesda
- 国际申请： PCT/US2022/026576 2022.04.27
- 进入国家日期： 2023-10-12
- 主分类号： A61K39/215
- IPC分类号： A61K39/215 ; A61K39/00 ; A61K39/155 ; A61P31/14 ; A61P37/04 ; C07K14/005 ; C12N15/86
摘要：
Recombinant chimeric bovine/human parainfluenza virus 3 (rB/HPIV3) vectors expressing a recombinant Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Spike (S) protein as well as methods of their use and manufacture, are provided. The rB/HPIV3 vector comprises a genome comprising a heterologous gene encoding the recombinant SARS-COV-2 S protein. Nucleic acid molecules comprising the sequence of the genome or antigenome of the disclosed rB/HPIV3 vectors are also provided. The disclosed rB/HPIV3 vectors can be used, for example, to induce an immune response to SARS-COV-2 and HPIV3 in a subject.
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