Invention Publication
- Patent Title: DISACCHARIDE LINKER, DISACCHARIDE-SMALL MOLECULE DRUG CONJUGATE AND SUGAR CHAIN FIXED-POINT ANTIBODY-DRUG CONJUGATE, AND PREPARATION METHOD THEREFOR AND USE THEREOF
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Application No.: US18278302Application Date: 2022-02-22
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Publication No.: US20240197900A1Publication Date: 2024-06-20
- Inventor: Wei HUANG , Feng TANG , Wei SHI , Shang JIAO , Siqi WANG
- Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Applicant Address: CN Shanghai
- Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES
- Current Assignee Address: CN Shanghai
- Priority: CN 2110198313.2 2021.02.22
- International Application: PCT/CN2022/077167 2022.02.22
- Date entered country: 2023-08-22
- Main IPC: A61K47/68
- IPC: A61K47/68 ; A61P35/00 ; C12N9/04 ; C12N9/24 ; C12P19/12
Abstract:
The present application relates to a disaccharide linker, a disaccharide-small molecule drug conjugate and a sugar chain fixed-point antibody-drug conjugate, a preparation method and the use thereof. The structure of the disaccharide linker is as shown in the following formula I. The present invention provides a new-type fixed-point and quantitative antibody-drug conjugate form, and the stability and cytotoxicity of the antibody-drug conjugate are improved.
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