公开(公告)号：US20240197900A1

公开(公告)日：2024-06-20

申请号：US18278302

申请日：2022-02-22

Applicant: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES

Inventor： Wei HUANG ,  Feng TANG ,  Wei SHI ,  Shang JIAO ,  Siqi WANG

IPC: A61K47/68 ,  A61P35/00 ,  C12N9/04 ,  C12N9/24 ,  C12P19/12

CPC classification number: A61K47/68031 ,  A61K47/68033 ,  A61K47/6883 ,  A61K47/6889 ,  A61P35/00 ,  C12N9/0006 ,  C12N9/2402 ,  C12P19/12 ,  C12Y101/03009 ,  C12Y302/01169

Abstract: The present application relates to a disaccharide linker, a disaccharide-small molecule drug conjugate and a sugar chain fixed-point antibody-drug conjugate, a preparation method and the use thereof. The structure of the disaccharide linker is as shown in the following formula I. The present invention provides a new-type fixed-point and quantitative antibody-drug conjugate form, and the stability and cytotoxicity of the antibody-drug conjugate are improved.