- 专利标题: ENZYMATICALLY-CLEAVABLE GLYCIDYL METHACRYLATE HYALURONIC ACID
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申请号: US18555956申请日: 2022-04-20
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公开(公告)号: US20240207420A1公开(公告)日: 2024-06-27
- 发明人: Christine E. Schmidt , Mary M. Kasper
- 申请人: University of Florida Research Foundation, Inc.
- 申请人地址: US FL Gainesville
- 专利权人: University of Florida Research Foundation, Inc.
- 当前专利权人: University of Florida Research Foundation, Inc.
- 当前专利权人地址: US FL Gainesville
- 国际申请: PCT/US2022/071823 2022.04.20
- 进入国家日期: 2023-10-18
- 主分类号: A61K47/61
- IPC分类号: A61K47/61 ; A61K9/06 ; A61K38/36 ; A61K47/46
摘要:
Disclosed herein is a hydrogel comprising hyaluronic acid polymers that are at least partially crosslinked with fibrinogen molecules. Also disclosed is a composition comprising a glycidyl methacrylate hyaluronic acid monomer chemically conjugated to a fibrinogen molecule. Also disclosed is a method for producing a hydrogel that involves combining the disclosed composition containing GMHA-Fib precursors with an effective amount of a photoinitiator and light (e.g. UV light) to crosslink unconjugated methacrylate sites through free-radical polymerization. Also disclosed is a method for treating a subject with a peripheral nerve injury that involves implanting the disclosed hydrogel at the site of the injury to promote neural regeneration.
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