-
1.发明授权公开(公告)号：US12133881B2
公开(公告)日：2024-11-05
申请号：US17263263
申请日：2019-08-01
Inventor： Christine E. Schmidt , Sahba Mobini
IPC: A61K38/18 , A61K9/00 , A61K9/06 , A61K35/28 , A61K35/32 , A61K35/34 , A61K35/44 , C12N5/071 , C12N5/077 , C12N5/0775 , C12N13/00
Abstract: Disclosed herein is a method of treating a subject for a disease, disorder, or condition that involves administering to the subject a composition comprising a secretome derived from electrically stimulated cells. Also disclosed herein is an enhanced secretome produced by a process comprising collecting cells from a subject, culturing the cells in a serum free medium for at least 1 day while stimulating the cells with electric pulses, and collecting the secretome produced by the electrically-stimulated cells. Also disclosed herein is a pharmaceutical composition comprising an enhanced secretome derived from electrically stimulated cells contained within a biocompatible hydrogel in an amount effective to treat a disease or disorder.
-
公开(公告)号：US20240207420A1
公开(公告)日：2024-06-27
申请号：US18555956
申请日：2022-04-20
Inventor： Christine E. Schmidt , Mary M. Kasper
CPC classification number: A61K47/61 , A61K9/06 , A61K38/363 , A61K47/46
Abstract: Disclosed herein is a hydrogel comprising hyaluronic acid polymers that are at least partially crosslinked with fibrinogen molecules. Also disclosed is a composition comprising a glycidyl methacrylate hyaluronic acid monomer chemically conjugated to a fibrinogen molecule. Also disclosed is a method for producing a hydrogel that involves combining the disclosed composition containing GMHA-Fib precursors with an effective amount of a photoinitiator and light (e.g. UV light) to crosslink unconjugated methacrylate sites through free-radical polymerization. Also disclosed is a method for treating a subject with a peripheral nerve injury that involves implanting the disclosed hydrogel at the site of the injury to promote neural regeneration.
-
3.发明申请公开(公告)号：US20210187070A1
公开(公告)日：2021-06-24
申请号：US17263263
申请日：2019-08-01
Inventor： Christine E. Schmidt , Sahba Mobini
IPC: A61K38/18 , A61K9/00 , A61K35/28 , A61K35/34 , A61K35/32 , A61K35/44 , C12N13/00 , C12N5/0775 , C12N5/077 , C12N5/071 , A61K9/06
Abstract: Disclosed herein is a method of treating a subject for a disease, disorder, or condition that involves administering to the subject a composition comprising a secretome derived from electrically stimulated cells. Also disclosed herein is an enhanced secretome produced by a process comprising collecting cells from a subject, culturing the cells in a serum free medium for at least 1 day while stimulating the cells with electric pulses, and collecting the secretome produced by the electrically-stimulated cells. Also disclosed herein is a pharmaceutical composition comprising an enhanced secretome derived from electrically stimulated cells contained within a biocompatible hydrogel in an amount effective to treat a disease or disorder.
-
公开(公告)号：US11007278B2
公开(公告)日：2021-05-18
申请号：US16844222
申请日：2020-04-09
Inventor： John Hardy , Christine E. Schmidt
Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
-
公开(公告)号：US10898609B2
公开(公告)日：2021-01-26
申请号：US15744942
申请日：2016-07-14
Inventor： Christine E. Schmidt , Rebecca Ann Wachs , Robert Chase Cornelison
Abstract: Provided herein are methods of producing an acellular tissue product wherein the method can include the step of inducing apoptosis and washing the tissue after induction of apoptosis with a tonic solution. Also provided herein are acellular tissue products produced by the methods provided herein and methods of administering the acellular tissue products to a subject in need thereof.
-
Patent Agency Ranking
公开(公告)号：US10653798B2
公开(公告)日：2020-05-19
申请号：US15578292
申请日：2016-06-01
Inventor： John Hardy , Christine E. Schmidt
Abstract: Embodiments of the present disclosure provide for electroactive supramolecular polymeric assemblies, methods of making electroactive supramolecular polymeric assemblies, methods of using electroactive supramolecular polymeric assemblies, and the like.
-
公开(公告)号：US12195761B2
公开(公告)日：2025-01-14
申请号：US17236352
申请日：2021-04-21
Inventor： Christine E. Schmidt , Benjamin Scott Spearman , Tran Ngo
IPC: C12N5/071 , C12N5/0775 , G01N33/50
Abstract: The disclosure provides 3D bioprinted test beds and methods of making the 3D bioprinted teste beds, methods of using the 3D bioprinted test beds for testing and/or comparatively testing two or more test compounds on cell growth and/or behavior, as well as biocompatible methacrylated hyaluronic acid-based bioinks for printing the 3D test beds and/or other articles. The 3D test beds and bioinks include a hydrogel material/precursor and can include extracellular matrix components.
-
公开(公告)号：US09783637B2
公开(公告)日：2017-10-10
申请号：US14222000
申请日：2014-03-21
Inventor： John Hardy , Christine E. Schmidt
IPC: A61K47/34 , C08G69/00 , A61K31/573 , A61K31/00 , A61K41/00 , A61K47/48 , C08G73/02 , C08L65/00 , C08L67/04 , A61L27/54
CPC classification number: C08G69/00 , A61K31/00 , A61K31/573 , A61K41/0042 , A61K47/59 , A61K47/60 , A61L27/54 , C08G73/024 , C08G73/0266 , C08G73/0273 , C08L65/00 , C08L67/04
Abstract: A biodegradable electroactive material can be doped with a drug and the drug can be delivered to a living subject by stimulating the material with an electrical potential. The material (in this case a polymer) has an electrochemically responsive oligoaniline block terminated with a carboxylic acid moiety and is linked to an alcohol-terminated diol by an ester bond. Advantageously, the diol is PEG-400, PEG-2000, PCL-530, or PCL-2000.
-
公开(公告)号：US10918767B2
公开(公告)日：2021-02-16
申请号：US15573270
申请日：2016-05-11
Inventor： Carlos Rinaldi , Christine E. Schmidt , Christopher Lacko , Zin Z. Khaing , Andrew Garcia
Abstract: The present disclosure provides magnetically templated tissue scaffolds, methods of making the magnetically templated tissue scaffolds, and various methods of employing the scaffolds for tissue growth and repair in vitro and in vivo, including peripheral nerve repair.
-
10.发明申请DRUG DELIVERY USING ELECTROCHEMICALLY-TRIGGERED BIODEGRADABLE ELECTROACTIVE MATERIALS 有权使用电化学触发的生物可降解电极材料进行药物输送公开(公告)号：US20150265712A1
公开(公告)日：2015-09-24
申请号：US14222000
申请日：2014-03-21
Inventor： John Hardy , Christine E. Schmidt
IPC: A61K47/34 , C08G69/00 , A61K41/00 , A61K31/573
CPC classification number: C08G69/00 , A61K31/00 , A61K31/573 , A61K41/0042 , A61K47/59 , A61K47/60 , A61L27/54 , C08G73/024 , C08G73/0266 , C08G73/0273 , C08L65/00 , C08L67/04
Abstract: A biodegradable electroactive material can be doped with a drug and the drug can be delivered to a living subject by stimulating the material with an electrical potential. The material (in this case a polymer) has an electrochemically responsive oligoaniline block terminated with a carboxylic acid moiety and is linked to an alcohol-terminated diol by an ester bond. Advantageously, the diol is PEG-400, PEG-2000, PCL-530, or PCL-2000.
Abstract translation: 可生物降解的电活性材料可以掺杂药物，并且可以通过用电位刺激材料将药物递送到活体受试者。 材料（在这种情况下为聚合物）具有用羧酸部分封端的电化学反应性的低聚苯胺嵌段，并通过酯键与醇封端的二醇连接。 有利地，二醇是PEG-400，PEG-2000，PCL-530或PCL-2000。
-
-
-
-
-
-
-
-
-
Search Results
10
records
(took 0.035 seconds)
