A method of, and system for, treatment of chronic and acute musculoskeletal conditions with therapeutic modalities is provided. The method and system treat an area of a body with a plurality of treatment sessions in which a treatment session thereof includes a synergistic combination of sequentially administered therapeutic modalities administered to the area of the body. The synergistic combination of sequentially administered therapeutic modalities includes laser therapy, capacitive resistive electric transfer therapy, shock wave therapy, and acoustical vibration therapy.