Invention Publication
- Patent Title: CELL POTENCY ASSAYS, PLATFORMS, AND METHODS OF USE
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Application No.: US18558026Application Date: 2022-04-29
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Publication No.: US20240210384A1Publication Date: 2024-06-27
- Inventor: Rebecca S. SCHNEIDER , Andres J. GARCIA , Wilbur A. LAM , Evelyn Kendall WILLIAMS , Karen E. MARTIN
- Applicant: GEORGIA TECH RESEARCH CORPORATION , EMORY UNIVERSITY
- Applicant Address: US GA Atlanta
- Assignee: GEORGIA TECH RESEARCH CORPORATION,EMORY UNIVERSITY
- Current Assignee: GEORGIA TECH RESEARCH CORPORATION,EMORY UNIVERSITY
- Current Assignee Address: US GA Atlanta
- International Application: PCT/US2022/027056 2022.04.29
- Date entered country: 2023-10-30
- Main IPC: G01N33/50
- IPC: G01N33/50

Abstract:
A high-throughput, scalable, low-cost, on-chip microfluidic potency assay for nondifferentiated cells such as human mesenchymal stromal cells (hMSCs) with improved functional predictive power and recapitulation of in vivo secretory responses compared to traditional approaches. By comparison of hMSC secretory responses to functional hMSC-medicated immune cell suppression, on-chip microfluidic potency markers are identified with improved functional predictive power compared to traditional planar methods.
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