Wireless soft scalp electronics and virtual reality system for brain-machine interfaces

    公开(公告)号:US12236014B2

    公开(公告)日:2025-02-25

    申请号:US18563788

    申请日:2022-05-27

    Abstract: An exemplary wireless soft scalp electronic system and method are disclosed that can actuate commands for a brain-machine interface (BMI) or brain-computer-interface (BCI) by performing real-time, continuous classification. e.g., via a trained neural network, of motor imagery (MI) brain signals or of steady-state visually evoked potential (SSVEP) signals. In some embodiments, the exemplary system is configured as a low-profile, portable system that includes microneedle electrodes that can acquire EEG signals for a brain-machine interface controller. The microneedle electrodes may be configured as soft imperceptible gel-less epidermis-penetrating microneedle electrodes that can provide improved contact surface area and reduced electrode impedance density, e.g., to enhance EEG signals and the signal classification accuracy. The microneedle electrodes can be further integrated with soft electronics that can be mounted locally in proximity to the electrodes to reduce obtrusive wiring and improve signal acquisition quality.

    Massively parallel microfluidic cell analyzer for high throughput mechanophenotyping

    公开(公告)号:US12233413B2

    公开(公告)日:2025-02-25

    申请号:US18117612

    申请日:2023-03-06

    Abstract: A microfluidic device may include an inlet, an outlet, first and second channels arranged in parallel, a first sensor pair positioned along the first channel, and a second sensor pair positioned along the second channel. The first channel may include a first upstream zone, a first downstream zone, and a first constriction zone. The second channel may include a second upstream zone, a second downstream zone, and a second constriction zone. The first sensor pair may include a first entry sensor configured to detect a first cell flowing through the first upstream zone, and a first exit sensor configured to detect the first cell flowing through the first downstream zone. The second sensor pair may include a second entry sensor configured to detect a second cell flowing through the second upstream zone, and a second exit sensor configured to detect the second cell flowing through the second downstream zone.

    Microfluidic platform for refrigeration induced phase separation of aqueous-acetonitrile solutions

    公开(公告)号:US12220652B2

    公开(公告)日:2025-02-11

    申请号:US17597953

    申请日:2020-07-31

    Abstract: An embodiment of the disclosed technology provides a microfluidic cooling device including a microfluidic pathway and a thermoelectric cooling element. The microfluidic pathway can include an inlet to receive a sample at a first temperature and an outlet to output a first phase and second phase of the sample at a second temperature. The sample can include a first liquid, a second liquid, and a plurality of soluble particles. The first phase can include the first liquid and a portion of the soluble particles that is more soluble in the first liquid than second liquid. The second phase can include the second liquid and a portion of the soluble particles that more soluble in the second liquid than first liquid. The thermoelectric cooling element can be in thermal communication with the microfluidic pathway and can transition the sample from the first temperature to the second temperature.

    UNIFIED MACHINE LEARNING FRAMEWORK TO EMULATE DENSITY FUNCTIONAL THEORY SIMULATIONS

    公开(公告)号:US20250046402A1

    公开(公告)日:2025-02-06

    申请号:US18785064

    申请日:2024-07-26

    Abstract: A method comprising providing a training data set to a machine learning (ML) system, the training data set indicative of density functional theory (DFT) data for a plurality of materials, the DFT data representing atomic configurations for the plurality of materials, determining a fingerprint for the atomic configuration for each of the plurality of materials, inputting the fingerprints into a machine learning system, generating, with the machine learning system, electron charge density data for the plurality of materials, inputting the electron charge density data and the fingerprint into a machine learning system, and predicting, with the machine learning system, one or more DFT properties of the plurality of materials.

    SYNTHETIC MEMORY WITH INTERCEPTING RECOMBINASE FUNCTION

    公开(公告)号:US20250043287A1

    公开(公告)日:2025-02-06

    申请号:US18790573

    申请日:2024-07-31

    Inventor: Corey J. Wilson

    Abstract: Disclosed herein is a synthetic memory system, comprising: a recombinase; a modified transcription factor; and a first nucleic acid comprising a first attachment site, a second attachment site, and a target gene between said first attachment site and said second attachment site; wherein at least one of the first attachment site and the second attachment site comprises a modified DNA operator to which the modified transcription factor can reversibly bind; and wherein, when the modified transcription factor is bound to the modified DNA operator, the recombinase is blocked from binding to the attachment site comprising said modified DNA operator.

    WIRELESS BATTERYLESS SOFT SENSORS FOR AMBULATORY CARDIOVASCULAR HEALTH MONITORING

    公开(公告)号:US20250031998A1

    公开(公告)日:2025-01-30

    申请号:US18780633

    申请日:2024-07-23

    Abstract: An exemplary embodiment of the present disclosure provides a cardiovascular sensing system, comprising a sensor, an external antenna, and a controller. The sensor can be configured to be worn by a user. The sensor can comprise an inductive capacitive (LC) circuit. The sensor can be configured to deform in response to a strain induced by vibrations of the heart of the user. The external antenna can be inductively coupled to the sensor. The external antenna can be configured to receive a signal from the LC circuit. The controller can be configured to determine a seismocardiogram (SCG) of the user based, at least in part, on the signal received by the LC circuit.

    HYDROGEL STRUCTURES AND METHODS OF MAKING AND USE THEREOF

    公开(公告)号:US20250011727A1

    公开(公告)日:2025-01-09

    申请号:US18705735

    申请日:2022-10-28

    Abstract: Disclosed herein are hydrogel structures and methods of making and use thereof. For example, disclosed herein are methods of making a device comprising a hydrogel matrix and a first chamber in the hydrogel matrix, the hydrogel matrix being derived from a prepolymer and the first chamber being perfusable. The methods can, for example, comprise blocking a first portion of a pre-polymerization solution with a first photomask, the pi-polymerization solution comprising the prepolymer, such that the pre-polymerization solution comprises an exposed portion and a first blocked portion. The methods can further comprise irradiating the exposed portion of the pi-polymerization solution and the first photomask with electromagnetic radiation, the first photomask being substantially opaque to the electromagnetic radiation. In some examples, the prepolymer within the exposed portion of pre-polymerization solution photopolymerizes to form the hydrogel matrix and the prepolymer within the first blocked portion does not photopolymerize and forms the first chamber.

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