- 专利标题： CD33 SPECIFIC CHIMERIC ANTIGEN RECEPTORS
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申请号： US18462207申请日： 2023-09-06
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公开(公告)号： US20240254188A1公开(公告)日： 2024-08-01
- 发明人: Rutul SHAH , Tim CHAN , Peter EMTAGE , Ramya YARLAGADDA
- 申请人： PRECIGEN, INC.
- 申请人地址： US MD Germantown
- 专利权人： PRECIGEN, INC.
- 当前专利权人： PRECIGEN, INC.
- 当前专利权人地址： US MD Germantown
- 主分类号： C07K14/705
- IPC分类号： C07K14/705 ; A61K39/00 ; C07K14/71 ; C07K14/725 ; C07K16/28 ; C12N5/0783
摘要：
Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders such as acute myeloid leukemia (AML), and relapsed or refractory AML.
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