公开(公告)号：US12060585B2

公开(公告)日：2024-08-13

申请号：US17302514

申请日：2021-05-05

申请人： PRECIGEN, INC.

发明人： Rutul Shah ,  Peter Emtage ,  Ramya Yarlagadda

IPC分类号： C12N9/12 ,  A61K35/17 ,  A61K39/00 ,  A61K39/395 ,  A61P35/00 ,  C07K14/54 ,  C07K14/705 ,  C07K14/71 ,  C07K14/725 ,  C07K16/28 ,  C07K16/32

CPC分类号： C12N9/12 ,  A61K35/17 ,  A61K39/3955 ,  A61P35/00 ,  C07K14/5443 ,  C07K14/70503 ,  C07K14/7051 ,  C07K14/70521 ,  C07K14/70578 ,  C07K14/70592 ,  C07K14/70596 ,  C07K14/71 ,  C07K16/2887 ,  C07K16/32 ,  C12Y207/10001 ,  A61K2039/505 ,  C07K2317/622 ,  C07K2317/732 ,  C07K2317/734 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2319/33

摘要： Disclosed herein are polynucleotides encoding cell tags for use in immunotherapeutic applications, and systems comprising polynucleotide cell tags for regulating the activity of a cell. The compositions, methods and systems described herein provide tools for regulating activity of genetically engineered cells in a subject.

公开(公告)号：US12018310B2

公开(公告)日：2024-06-25

申请号：US17447568

申请日：2021-09-13

申请人： PRECIGEN, INC.

发明人： Xinhua Zhao ,  Tina Huynh ,  Jeffrey Orth ,  Lily Yuin Chao ,  James Kealey

IPC分类号： C12P7/04 ,  C12N1/20 ,  C12N15/74

CPC分类号： C12P7/04 ,  C12N1/20 ,  C12N15/74

摘要： Genetically modified microorganisms that have the ability to convert carbon substrates into chemical products such as 1,4-BDO are disclosed. For example, genetically modified methanotrophs that are capable of generating 1,4-BDO at high titers from a methane source are disclosed. Methods of making these genetically modified microorganisms and methods of using them are also disclosed.

公开(公告)号：US20230279057A1

公开(公告)日：2023-09-07

申请号：US18074302

申请日：2022-12-02

申请人： Precigen, Inc.

发明人： Douglas E. BROUGH ,  Cheryl G. BOLINGER ,  Ramya YARLAGADDA ,  Vinodhbabu KURELLA ,  Prabakaran PONRAJ ,  Simon METENOU ,  Kuan-Fu DING

IPC分类号： C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/29 ,  A61K48/00 ,  C07K14/02 ,  C12N15/861

CPC分类号： C07K14/005 ,  A61K39/12 ,  C12N7/00 ,  A61K39/292 ,  A61K48/0066 ,  C07K14/02 ,  C12N15/861 ,  C07K2319/33 ,  C12N2710/20022 ,  C12N2710/20034

摘要： Provided herein are engineered hepatitis B virus (HBV) molecular vaccine constructs. Vaccine constructs can also include ligand-inducible engineered gene switch systems for modulating expression of heterologous genes, such as a cytokines, in host cells.

公开(公告)号：US20220153866A1

公开(公告)日：2022-05-19

申请号：US17650018

申请日：2022-02-04

申请人： PRECIGEN, INC.

发明人： Helen SABZEVARI ,  Rutul SHAH

IPC分类号： C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  C07K14/71 ,  C07K14/54 ,  C07K14/005 ,  C12N7/00 ,  C12N5/0783 ,  A61P35/00 ,  A61K35/17 ,  A61K9/00

摘要： Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.

公开(公告)号：US11319380B2

公开(公告)日：2022-05-03

申请号：US16431193

申请日：2019-06-04

申请人： Precigen, Inc.

发明人： Helen Sabzevari ,  Rutul R. Shah

IPC分类号： C07K16/30 ,  C07K14/705 ,  C07K14/725 ,  C07K14/71 ,  C07K14/54 ,  C07K14/005 ,  C12N7/00 ,  C12N5/0783 ,  A61P35/00 ,  A61K35/17 ,  A61K9/00 ,  A61K39/00 ,  A61K38/00

摘要： Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from an anti-MUC16 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders.

公开(公告)号：US11118168B2

公开(公告)日：2021-09-14

申请号：US16001759

申请日：2018-06-06

申请人： Precigen, Inc.

发明人： Rutul Shah ,  Peter Emtage ,  Ramya Yarlagadda

IPC分类号： C12N9/12 ,  A61K39/395 ,  C07K14/705 ,  A61K35/17 ,  C07K14/71 ,  C07K16/28 ,  C07K14/725 ,  A61P35/00 ,  C07K14/54 ,  C07K16/32 ,  A61K39/00

摘要： Disclosed herein are polynucleotides encoding cell tags for use in immunotherapeutic applications, and systems comprising polynucleotide cell tags for regulating the activity of a cell. The compositions, methods and systems described herein provide tools for regulating activity of genetically engineered cells in a subject.

公开(公告)号：US20240263183A1

公开(公告)日：2024-08-08

申请号：US18426680

申请日：2024-01-30

申请人： PRECIGEN, INC.

发明人： Rutul R. SHAH ,  Thomas D. REED ,  Cheryl G. BOLINGER

IPC分类号： C12N15/63 ,  C07K14/54 ,  C07K14/725 ,  C12N15/10 ,  C12N15/85 ,  G01N33/68

CPC分类号： C12N15/635 ,  C07K14/5443 ,  C07K14/7051 ,  C12N15/1055 ,  C12N15/63 ,  C12N15/85 ,  G01N33/6845 ,  C07K2319/80 ,  C12N2800/90

摘要： Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and systems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell. The compositions, methods and systems described herein facilitate ligand dependent expression of polypeptides including but not limited to cytokines and antigen binding polypeptides.

公开(公告)号：US11998618B2

公开(公告)日：2024-06-04

申请号：US17125449

申请日：2020-12-17

申请人： PRECIGEN, INC.

发明人： Stephen Schauer ,  Darby Thomas ,  Gregory Robinson ,  Mark Pykett ,  Richard Thorn ,  Kirsten Gruis

IPC分类号： A61K48/00 ,  A61K38/17 ,  A61P25/00 ,  C07K14/47 ,  C12N15/86 ,  C12N15/864

CPC分类号： A61K48/0058 ,  A61K38/1709 ,  A61K48/005 ,  A61K48/0066 ,  A61K48/0075 ,  A61P25/00 ,  C07K14/47 ,  C12N15/86 ,  C12N15/8645 ,  C12N2750/14143 ,  C12N2830/002

摘要： The invention provides polynucleotides, vectors and viruses expressing frataxin and methods of treating Friedreich's Ataxia.

公开(公告)号：US11946054B2

公开(公告)日：2024-04-02

申请号：US16881871

申请日：2020-05-22

申请人： PRECIGEN, INC.

发明人： Rutul R. Shah ,  Thomas D. Reed ,  Cheryl G. Bolinger

IPC分类号： C12N15/63 ,  C07K14/54 ,  C07K14/725 ,  C12N15/10 ,  C12N15/85 ,  G01N33/68

CPC分类号： C12N15/635 ,  C07K14/5443 ,  C07K14/7051 ,  C12N15/1055 ,  C12N15/63 ,  C12N15/85 ,  G01N33/6845 ,  C07K2319/80 ,  C12N2800/90

摘要： Disclosed herein are polynucleotides encoding ligand-inducible gene switch polypeptides, and systems comprising gene switch polypeptides for modulating the expression of a heterologous gene and an interleukin in a host cell. The compositions, methods and systems described herein facilitate ligand dependent expression of polypeptides including but not limited to cytokines and antigen binding polypeptides.

公开(公告)号：US11787848B2

公开(公告)日：2023-10-17

申请号：US15616869

申请日：2017-06-07

申请人： Precigen, Inc.

发明人： Rutul Shah ,  Tim Chan ,  Peter Emtage ,  Ramya Yarlagadda

IPC分类号： C07K14/705 ,  C07K16/28 ,  A61K39/00 ,  C07K14/725 ,  C07K14/71 ,  C12N5/0783

CPC分类号： C07K14/70503 ,  A61K39/001104 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  C07K14/70575 ,  C07K14/70578 ,  C07K14/70596 ,  C07K14/71 ,  C07K16/2803 ,  C12N5/0636 ,  A61K2039/505 ,  A61K2039/5158 ,  A61K2039/57 ,  C07K2317/24 ,  C07K2317/622 ,  C07K2317/73 ,  C07K2319/00 ,  C07K2319/02 ,  C07K2319/03 ,  C12N2510/00

摘要： Provided herein are chimeric antigen receptors (CARs) for cancer therapy, and more particularly, CARs containing a scFv from a CD33 monoclonal antibody. Provided are immune effector cells containing such CARs, and methods of treating proliferative disorders such as acute myeloid leukemia (AML), and relapsed or refractory AML.