Among other things, disclosed herein are compositions and methods for using human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum. Compositions may improve skin health. Methods may include applying human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum over a host or host area, such as skin or mucosa to minimize the presence of one or more pathogenic microbes, maximize therapeutic effects of one or more additional therapeutics, and/or improve health of a host or host area. A method to minimize a pathogenic microbe may include applying to a surface a composition including human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum and an acceptable carrier. Compositions and methods may include a prebiotic or another microbe to maximize growth and/or metabolites (e.g., resulting from growth of a probiotic). Compositions and methods may include human-isolated or synthetic Alcaligenes faecalis, Bacillus altitudinis, Bacillus pumilus, Bacillus subtilis, or Janthinobacterium lividum metabolites.