- 专利标题： CONJUGATES COMPRISING A PHOSPHORUS(V) MOIETY AND A DRUG
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申请号： US18394303申请日： 2023-12-22
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公开(公告)号： US20240269313A1公开(公告)日： 2024-08-15
- 发明人: Marc-André KASPER , Philipp OCHTROP , Anil Pandurang JAGTAP , Swetlana WUNDER , Simon VOGT , Dominik SCHUMACHER , Jonas HELMA-SMETS
- 申请人： Tubulis GmbH
- 申请人地址： DE Planegg/Martinsried
- 专利权人： Tubulis GmbH
- 当前专利权人： Tubulis GmbH
- 当前专利权人地址： DE Planegg/Martinsried
- 优先权： EP 216022.8 2022.12.22 EP 193215.3 2023.08.24
- 主分类号： A61K47/68
- IPC分类号： A61K47/68 ; A61K47/54 ; A61P35/00
摘要：
The present invention relates to a conjugate having the formula (1):
wherein a receptor binding molecule (RBM) is connected with a drug moiety (D), the conjugate comprising a phosphorus(V) moiety. The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.
wherein a receptor binding molecule (RBM) is connected with a drug moiety (D), the conjugate comprising a phosphorus(V) moiety. The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.
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