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1.发明公开公开(公告)号：US20240182596A1
公开(公告)日：2024-06-06
申请号：US18489605
申请日：2023-10-18
申请人： Tubulis GmbH
发明人： Jonas Helma-Smets , Annette Vogl , Saskia Schmitt , Isabelle Mai , Sarah Herterich , Dominik Schumacher , Marc-André Kasper , Philipp Cyprys , Marcus Gerlach
CPC分类号： C07K16/3069 , A61K47/6869 , A61P35/00 , C07K2317/24 , C07K2317/92
摘要： The present invention relates to novel anti-NaPi2b antibodies, antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
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2.发明公开公开(公告)号：US20240190958A1
公开(公告)日：2024-06-13
申请号：US18489624
申请日：2023-10-18
申请人： Tubulis GmbH
发明人： Jonas Helma-Smets , Annette Vogl , Saskia Schmitt , Isabelle Mai , Sarah Herterich , Dominik Schumacher , Marc-André Kasper , Philipp Cyprys , Marcus Gerlach
CPC分类号： C07K16/28 , A61K47/68031 , A61K47/68037 , A61P35/00 , C07K2317/33 , C07K2317/565
摘要： The present invention relates to novel anti-NaPi2b antibodies, novel antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
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公开(公告)号：US20230330258A1
公开(公告)日：2023-10-19
申请号：US18054018
申请日：2022-11-09
发明人： Christian HACKENBERGER , Marc-André KASPER , Philipp OCHTROP , Jahaziel JAHZERAH , Paul MACHUI , Dominik SCHUMACHER , Jonas HELMA-SMETS , Isabelle MAI
CPC分类号： A61K47/6889 , C07F9/30
摘要： The present invention relates to a conjugate having the formula (I):
wherein a receptor binding molecule (RBM) is connected with a drug moiety (D). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.-
公开(公告)号：US20240269313A1
公开(公告)日：2024-08-15
申请号：US18394303
申请日：2023-12-22
申请人： Tubulis GmbH
发明人： Marc-André KASPER , Philipp OCHTROP , Anil Pandurang JAGTAP , Swetlana WUNDER , Simon VOGT , Dominik SCHUMACHER , Jonas HELMA-SMETS
CPC分类号： A61K47/6889 , A61K47/548 , A61K47/68031 , A61K47/68033 , A61K47/68035 , A61K47/68037 , A61K47/6809 , A61K47/6851 , A61P35/00
摘要： The present invention relates to a conjugate having the formula (1):
wherein a receptor binding molecule (RBM) is connected with a drug moiety (D), the conjugate comprising a phosphorus(V) moiety. The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.-
5.发明公开公开(公告)号：US20240245798A1
公开(公告)日：2024-07-25
申请号：US18489627
申请日：2023-10-18
申请人： Tubulis GmbH
发明人： Jonas Helma-Smets , Annette Vogl , Saskia Schmitt , Isabelle Mai , Sarah Herterich , Dominik Schumacher , Marc-André Kasper , Philipp Cyprys , Marcus Gerlach
CPC分类号： A61K47/6851 , A61K47/68037 , A61K47/6889 , A61P35/00 , C07K16/30 , C07K2317/77
摘要： The present invention relates to novel anti-TPBG antibody comprising Fc silencing mutations such as leucine (L) to alanine (A) substitution at the position 234 and 235 (LALA mutations), antibody-drug-conjugates (ADCs) based thereon as well as to therapeutic methods and uses thereof, particularly in relation to cancer treatment.
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公开(公告)号：US20230158154A1
公开(公告)日：2023-05-25
申请号：US18054063
申请日：2022-11-09
申请人： Tubulis GmbH
发明人： Marc-André KASPER , Paul MACHUI , Isabelle MAI , Annette VOGL , Saskia SCHMITT , Dominik SCHUMACHER , Jonas HELMA-SMETS
IPC分类号： A61K47/54 , A61K31/4745 , A61K47/68
CPC分类号： A61K47/545 , A61K31/4745 , A61K47/6803
摘要： The present invention relates to a conjugate having the formula (I):
wherein a receptor binding molecule (RBM) is connected with a camptothecin moiety (C). The present invention also relates to intermediates for producing the same, methods of preparing the same, pharmaceutical compositions comprising the same, as well as uses thereof.
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