Invention Publication
- Patent Title: RITUXIMAB-RESISTANT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
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Application No.: US18395996Application Date: 2023-12-26
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Publication No.: US20240277763A1Publication Date: 2024-08-22
- Inventor: Thomas Charles PERTEL , Barbra Johnson SASU , Mark W. LEONARD
- Applicant: ALLOGENE THERAPEUTICS, INC.
- Applicant Address: US CA South San Francisco
- Assignee: ALLOGENE THERAPEUTICS, INC.
- Current Assignee: ALLOGENE THERAPEUTICS, INC.
- Current Assignee Address: US CA South San Francisco
- The original application number of the division: US16857573 2020.04.24
- Main IPC: A61K35/17
- IPC: A61K35/17 ; A61K39/00 ; A61P35/00 ; C07K14/705 ; C07K16/28 ; C12N5/0783
Abstract:
Provided herein are polynucleotides encoding chimeric antigen receptors (CARs) comprising a CD19 antigen binding domain that specifically birnds to CD19 and is resistant to rituximab binding; and immune cells comprising these CD19-specific CARs, e.g., CAR-T cells. Also provided are methods of making and using these CD19-specific CARs, and immune cells comprising these CD19-specific CARs.
Information query
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