- 专利标题： REVERSE GENETICS-BASED COMPOSITIONS OF ATTENUATED RECOMBINANT SARS-COV-2
-
申请号： US18612258申请日： 2024-03-21
-
公开(公告)号： US20240307525A1公开(公告)日： 2024-09-19
- 发明人: Luis Martinez-Sobrido , Chengjin Ye
- 申请人： TEXAS BIOMEDICAL RESEARCH INSTITUTE
- 申请人地址： US TX San Antonio
- 专利权人： TEXAS BIOMEDICAL RESEARCH INSTITUTE
- 当前专利权人： TEXAS BIOMEDICAL RESEARCH INSTITUTE
- 当前专利权人地址： US TX San Antonio
- 主分类号： A61K39/215
- IPC分类号： A61K39/215 ; A61P31/14 ; C07K14/005 ; C12N7/00 ; C12N15/85 ; G01N33/68
摘要：
Provided here are compositions for a bacterial artificial chromosome-based construct containing a replication-competent recombinant severe acute respiratory syndrome coronavirus-2 (rSARS-CoV-2) genome and methods of making such compositions and uses thereof. The rSARS-Cov-2 provided herein can be attenuated and safely worked with under BLS-2+ conditions.
信息查询
