- 专利标题： IMMUNE CELLS ENGINEERED TO PROMOTE THANOTRANSMISSION AND USES THEREOF
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申请号： US18575715申请日： 2022-06-29
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公开(公告)号： US20240316104A1公开(公告)日： 2024-09-26
- 发明人: Darby Rye Schmidt , Niranjana Aditi Nagarajan , William Joseph Kaiser , Peter Joseph Gough , Sabin Dhakal , Alexis Benoit Hubaud
- 申请人： Flagship Pioneering Innovations V, iNC.
- 申请人地址： US MA Cambridge
- 专利权人： Flagship Pioneering Innovations V, iNC.
- 当前专利权人： Flagship Pioneering Innovations V, iNC.
- 当前专利权人地址： US MA Cambridge
- 国际申请： PCT/US2022/035612 2022.06.29
- 进入国家日期： 2023-12-29
- 主分类号： A61K35/17
- IPC分类号： A61K35/17 ; A61K39/00 ; A61P35/00 ; C07K14/47 ; C07K16/28 ; C12N5/0783 ; C12N9/12 ; C12N15/63
摘要：
In certain aspects, the disclosure relates to an immune cell that has been engineered to comprise one or more heterologous polynucleotides that promote thanotransmission by the immune cell. The immune cell may also comprise one or more nucleic acid sequences that encode a chimeric antigen receptor (CAR). Methods of promoting thanotransmission, promoting immune response, and treating cancer using the engineered immune cells are also disclosed.
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