公开(公告)号：US20230114107A1

公开(公告)日：2023-04-13

申请号：US17787287

申请日：2020-12-17

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Anthony Michael Barsotti ,  Alexandra Masu Cantley ,  Jason Park ,  Darby Rye Schmidt ,  Peter Joseph Gough

IPC分类号： A61K31/472 ,  A61K31/69 ,  A61K31/635 ,  A61K35/768 ,  A61K35/761 ,  A61K31/444 ,  A61K31/436 ,  A61K31/496 ,  A61K31/506 ,  A61K31/5025 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/437 ,  A61K31/4545 ,  A61K31/519 ,  A61K31/502 ,  A61K39/395 ,  A61K31/4365 ,  A61K31/4375 ,  A61P35/00

摘要： The invention provides methods of treating a cancer in a subject, comprising administering to the subject a combination of (a) an anti-neoplastic agent and (b) an agent that induces iron-dependent cellular disassembly, thereby treating the cancer in the subject. In some embodiments, the cancer is resistant to the anti-neoplastic agent.

公开(公告)号：US20220325287A1

公开(公告)日：2022-10-13

申请号：US17710965

申请日：2022-03-31

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Darby Rye Schmidt ,  Niranjana Aditi Nagarajan ,  William Joseph Kaiser ,  Peter Joseph Gough ,  Sabin Dhakal ,  Alexis Benoit Hubaud

IPC分类号： C12N15/62 ,  A61P35/00 ,  A61K9/00 ,  A61K38/00 ,  C07K14/01 ,  C07K14/555 ,  C07K14/54 ,  C12N15/861

摘要： In certain aspects, the disclosure relates to a nucleic acid molecule encoding two or more different thanotransmission polypeptides. Thanotransmission is communication between cells that is a result of activation of a cell turnover pathway in a target cell, which signals a responding cell to undergo a biological response. Vectors (e.g., engineered viruses, plasmids and transposons), cells and pharmaceutical compositions comprising one or more nucleic acid molecules encoding two or more thanotransmision polypeptides are also disclosed. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are further disclosed.

公开(公告)号：US20230355804A1

公开(公告)日：2023-11-09

申请号：US18013409

申请日：2021-06-29

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Darby Rye Schmidt ,  Niranjana Aditi Nagarajan ,  William Joseph Kaiser ,  Peter Joseph Gough ,  Sabin Dhakal

IPC分类号： A61K48/00 ,  C12N7/00 ,  A61K39/09 ,  A61K39/07 ,  A61K39/00 ,  A61K39/395 ,  A61K31/167 ,  A61K31/18 ,  A61K31/4045 ,  A61K31/165 ,  A61K31/4406 ,  A61K31/506 ,  A61P35/00 ,  C07K14/705 ,  C07K14/535 ,  C07K14/545 ,  C07K14/55 ,  C07K14/54 ,  C07K14/525 ,  C07K14/57 ,  C12N9/12

CPC分类号： A61K48/0041 ,  C12N7/00 ,  A61K39/092 ,  A61K39/07 ,  A61K39/4631 ,  A61K39/3955 ,  A61K31/167 ,  A61K31/18 ,  A61K31/4045 ,  A61K31/165 ,  A61K31/4406 ,  A61K31/506 ,  A61P35/00 ,  C07K14/70578 ,  C07K14/705 ,  C07K14/535 ,  C07K14/545 ,  C07K14/55 ,  C07K14/5406 ,  C07K14/5434 ,  C07K14/5443 ,  C07K14/525 ,  C07K14/57 ,  C12N9/12 ,  C12Y207/11001 ,  C12N2710/16622 ,  C12N2710/16671 ,  C12N2710/24122 ,  C12N2710/16632 ,  A61K2039/585

摘要： In certain aspects, the disclosure relates to a virus engineered to comprise one or more polynucleotides that promote thanotransmission by a target cell. Thanotransmission is communication between cells that is a result of activation of a cell turnover pathway in a target cell, which signals a responding cell to undergo a biological response. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are also disclosed.

公开(公告)号：US20240058279A1

公开(公告)日：2024-02-22

申请号：US18268920

申请日：2021-12-21

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Peter Joseph Gough ,  Darby Schmidt ,  Victoria Diane Kutilek ,  Anthony Michael Barsotti ,  Raju Varaha Laxmi N. Pusapati

IPC分类号： A61K31/095 ,  A61P43/00 ,  C12N5/00

CPC分类号： A61K31/095 ,  A61P43/00 ,  C12N5/0018

摘要： The disclosure provides methods of treating a tissue, organ, organoid or organ culture, the method comprising treating a tissue, organ, organoid or organ culture in vitro with a composition comprising one or more cell turnover factors produced by cells exposed to a stress condition. The disclosure also provides methods of increasing regeneration of a tissue in an organ of a subject, the method comprising administering to the subject a composition comprising one or more cell turnover factors produced by cells exposed to a stress condition, wherein the composition is administered to the subject in an amount sufficient to increase regeneration of the tissue relative to a subject that is not treated with the composition.

公开(公告)号：US20240316104A1

公开(公告)日：2024-09-26

申请号：US18575715

申请日：2022-06-29

申请人： Flagship Pioneering Innovations V, iNC.

发明人： Darby Rye Schmidt ,  Niranjana Aditi Nagarajan ,  William Joseph Kaiser ,  Peter Joseph Gough ,  Sabin Dhakal ,  Alexis Benoit Hubaud

IPC分类号： A61K35/17 ,  A61K39/00 ,  A61P35/00 ,  C07K14/47 ,  C07K16/28 ,  C12N5/0783 ,  C12N9/12 ,  C12N15/63

CPC分类号： A61K35/17 ,  A61K39/4611 ,  A61K39/4631 ,  A61K39/464468 ,  A61P35/00 ,  C07K14/4747 ,  C07K16/2818 ,  C07K16/2827 ,  C12N5/0638 ,  C12N9/12 ,  C12N15/63 ,  A61K2039/505 ,  A61K2239/13 ,  A61K2239/17 ,  A61K2239/21 ,  C12N2510/00 ,  C12Y207/11001

摘要： In certain aspects, the disclosure relates to an immune cell that has been engineered to comprise one or more heterologous polynucleotides that promote thanotransmission by the immune cell. The immune cell may also comprise one or more nucleic acid sequences that encode a chimeric antigen receptor (CAR). Methods of promoting thanotransmission, promoting immune response, and treating cancer using the engineered immune cells are also disclosed.

公开(公告)号：US20240174732A1

公开(公告)日：2024-05-30

申请号：US18481993

申请日：2023-10-05

申请人： Flagship Pioneering Innovations V, Inc.

发明人： Benjamin C. Blum ,  Alexis Benoit Hubaud ,  Peter Joseph Gough ,  Sabin Dhakal ,  Shreyas Jogidas Jadhav ,  Lauren Jessica Lahey ,  Erik Christian Hett ,  Christopher Ryan Shaler ,  Loren Matthew Brown ,  Xuqing Zhang ,  Yeon Sook Choi

IPC分类号： C07K14/705 ,  A61K31/7105 ,  A61P35/00 ,  C07K14/47 ,  C07K14/54 ,  C12N9/12

CPC分类号： C07K14/70596 ,  A61K31/7105 ,  A61P35/00 ,  C07K14/4747 ,  C07K14/5434 ,  C12N9/12 ,  C12Y207/11001 ,  C07K2319/33 ,  C07K2319/50 ,  C07K2319/735 ,  C12N2830/50 ,  C12N2840/10

摘要： In certain aspects, the disclosure relates to a nucleic acid molecule encoding one or more different thanotransmission polypeptides. Vectors (e.g., engineered viruses, plasmids and transposons), cells and pharmaceutical compositions comprising one or more nucleic acid molecules encoding one or more thanotransmission polypeptides are also disclosed. Methods of promoting thanotransmission by a target cell, methods of promoting an immune response in a subject, and methods of treating cancer in a subject are further disclosed.