- 专利标题: PREPARATION METHOD FOR HEPATITIS B VIRUS NUCLEOCAPSID INHIBITOR
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申请号: US18291212申请日: 2022-07-22
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公开(公告)号: US20240336607A1公开(公告)日: 2024-10-10
- 发明人: Gang LIU , Bo LIANG , Huanming CHEN , Zhaojian JIANG
- 申请人: Shanghai Zhimeng Biopharma, Inc.
- 申请人地址: CN Pudong New Area, Shanghai
- 专利权人: Shanghai Zhimeng Biopharma, Inc.
- 当前专利权人: Shanghai Zhimeng Biopharma, Inc.
- 当前专利权人地址: CN Pudong New Area, Shanghai
- 优先权: CN 2110839582.2 2021.07.23
- 国际申请: PCT/CN2022/107463 2022.07.22
- 进入国家日期: 2024-01-22
- 主分类号: C07D413/14
- IPC分类号: C07D413/14 ; A61K31/422
摘要:
A method for preparing a hepatitis B virus nucleocapsid inhibitor is provided. Specifically, the method involves a novel procedure for preparing a compound represented by formula (I) (each group is as defined in the description) by an optimization process. The method can significantly enhance the yield, improve the product purity, and significantly reduce genotoxic impurities in the product. Also disclosed is a new intermediate for the preparation of the compound represented by formula (I).
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