公开(公告)号：US20240336607A1

公开(公告)日：2024-10-10

申请号：US18291212

申请日：2022-07-22

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Gang LIU ,  Bo LIANG ,  Huanming CHEN ,  Zhaojian JIANG

IPC分类号： C07D413/14 ,  A61K31/422

CPC分类号： C07D413/14 ,  A61K31/422

摘要： A method for preparing a hepatitis B virus nucleocapsid inhibitor is provided. Specifically, the method involves a novel procedure for preparing a compound represented by formula (I) (each group is as defined in the description) by an optimization process. The method can significantly enhance the yield, improve the product purity, and significantly reduce genotoxic impurities in the product. Also disclosed is a new intermediate for the preparation of the compound represented by formula (I).

公开(公告)号：US20220340563A1

公开(公告)日：2022-10-27

申请号：US17636164

申请日：2020-08-12

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Bo LIANG ,  Qiu JIN ,  Huanming CHEN ,  Zhijun ZHANG ,  Tian XIA ,  Bo HUA ,  Gang LIU

IPC分类号： C07D471/04

摘要： 2-aminopyrimidine compounds and pharmaceutical compositions and uses thereof are provided. Specifically, the 2-aminopyrimidine compounds have a structure as shown in formula I. The compounds are suitable for use in the fields of anti-virus and anti-infection, as well as treatment of diseases such as autoimmune diseases and tumors.

公开(公告)号：US20230077155A1

公开(公告)日：2023-03-09

申请号：US17791613

申请日：2021-08-05

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Bo LIANG ,  Gang LIU ,  Huanming CHEN

IPC分类号： C07D217/04 ,  C07D401/04 ,  C07D471/04 ,  C07D409/04 ,  C07D223/16

摘要： A tetrahydroisoquinoline compound as a potassium channel modulator and preparation and application thereof. Specifically, the compound has the structure as shown in formula A.

公开(公告)号：US20220227721A1

公开(公告)日：2022-07-21

申请号：US17715935

申请日：2022-04-07

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming CHEN ,  Bo LIANG

IPC分类号： C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical application thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US11365181B2

公开(公告)日：2022-06-21

申请号：US17057457

申请日：2019-05-22

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming Chen ,  Bo Liang

IPC分类号： C07D471/04 ,  C07D265/30 ,  A61K31/165 ,  C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US20210163429A1

公开(公告)日：2021-06-03

申请号：US17057457

申请日：2019-05-22

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Huanming CHEN ,  Bo LIANG

IPC分类号： C07D267/14 ,  C07D495/04

摘要： p-phenylenediamine derivatives as potassium channel regulators and preparation methods and medical applications thereof. A compound represented by general formula A or a pharmaceutically acceptable salt thereof. A preparation method of the compound and a use of the same as a potassium channel opener.

公开(公告)号：US20230212125A1

公开(公告)日：2023-07-06

申请号：US17642387

申请日：2021-12-20

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Bo LIANG ,  Gang LIU ,  Huanming CHEN

IPC分类号： C07D217/04

CPC分类号： C07D217/04

摘要： A compound as a potassium channel regulator and preparation and use thereof are described. Specifically, the compound has the structure shown in formula A. A preparation method of the compound and its use as a potassium channel regulator in a medicament and a pharmaceutical composition are also described.

公开(公告)号：US20230054304A1

公开(公告)日：2023-02-23

申请号：US17783796

申请日：2020-12-10

申请人： Shanghai Zhimeng Biopharma, Inc.

发明人： Bo LIANG ,  Huanming CHEN ,  Gang LIU ,  Zhijun ZHANG ,  Tian XIA ,  Bo HUA ,  Qiu JIN

IPC分类号： C07D413/04 ,  C07F9/6584 ,  C07D413/14 ,  C07H13/10 ,  C07D263/58 ,  C07D493/04 ,  C07D265/18 ,  C07D498/10

摘要： Disclosed are a compound having a neuroprotective effect, a preparation method therefor and a use thereof. Specifically, the compound has the structure shown by formula I, the definition of each group and substituent being as described in the description. Further disclosed are a preparation method for the compound and a use thereof for neuroprotection.

公开(公告)号：US20220227713A1

公开(公告)日：2022-07-21

申请号：US17614780

申请日：2020-05-26

申请人： Shanghai Zhimeng Biopharma Inc.

发明人： Bo LIANG ,  Qiu JIN ,  Huanming CHEN ,  Zhijun ZHANG ,  Bo HUA

IPC分类号： C07D223/16 ,  C07D409/06

摘要： A tetrahydro-1H-benzazepine compound as a potassium channel modulator, a preparation method, and a medicament containing the compound are provided. Specifically, the compound has the structure shown by formula A, in which the definitions of each group and substituent are described in the description. A preparation method for the compound and its use as potassium channel modulator are also described.