- 专利标题： ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS
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申请号： US18618511申请日： 2024-03-27
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公开(公告)号： US20240343697A1公开(公告)日： 2024-10-17
- 发明人: Alejandro VILLAGRA , Alan P. KOZIKOWSKI , Sida SHEN
- 申请人： The George Washington University, A Congressionally Chartered Not-for-Profit Corporation , The Board of Trustees of the University of Illinois
- 申请人地址： US DC Washington
- 专利权人： The George Washington University, A Congressionally Chartered Not-for-Profit Corporation,The Board of Trustees of the University of Illinois
- 当前专利权人： The George Washington University, A Congressionally Chartered Not-for-Profit Corporation,The Board of Trustees of the University of Illinois
- 当前专利权人地址： US DC Washington; US IL Urbana
- 主分类号： C07D261/18
- IPC分类号： C07D261/18 ; A61K45/06 ; A61P35/00 ; C07D413/06 ; C07D417/06 ; C07D471/04
摘要：
The present disclosure provides compounds represented by Formula I:
and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.
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