专利检索 ap:("The George Washington University, A Congressionally Chartered Not-for-Profit Corporation" OR "The Board of Trustees of the University of Illinois") AND inv:"Alan P. KOZIKOWSKI" 第 1 页

1.

发明申请
ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS 有权

公开(公告)号：US20220153709A1

公开(公告)日：2022-05-19

申请号：US17590503

申请日：2022-02-01

申请人： The George Washington University, A Congressionally Chartered Not-for-Profit Corporation , The Board of Trustees of the University of Illinois

发明人： Alejandro VILLAGRA , Alan P. KOZIKOWSKI , Sida SHEN

IPC分类号： C07D261/18 , A61P35/00 , C07D413/06 , C07D417/06 , C07D471/04

摘要： The present disclosure provides compounds represented by Formula I: and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.

2.

发明公开
ISOXAZOLE HYDROXAMIC ACIDS AS HISTONE DEACETYLASE 6 INHIBITORS 审中-公开

公开(公告)号：US20240343697A1

公开(公告)日：2024-10-17

申请号：US18618511

申请日：2024-03-27

申请人： The George Washington University, A Congressionally Chartered Not-for-Profit Corporation , The Board of Trustees of the University of Illinois

发明人： Alejandro VILLAGRA , Alan P. KOZIKOWSKI , Sida SHEN

IPC分类号： C07D261/18 , A61K45/06 , A61P35/00 , C07D413/06 , C07D417/06 , C07D471/04

CPC分类号： C07D261/18 , A61P35/00 , C07D413/06 , C07D417/06 , C07D471/04 , A61K45/06

摘要： The present disclosure provides compounds represented by Formula I:

and pharmaceutically acceptable salts, solvates, e.g., hydrates, and prodrugs thereof, wherein X and n are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I for use to treat diseases and conditions, e.g., cancer, wherein inhibition of HDAC provides a benefit.