An adaptive programmable pump includes a pump housing, a diaphragm comprising a variable stiffness element attached to the pump housing, a piezoelectric element operatively connected to the diaphragm, and a control element coupled to the variable stiffness element, where the control element is configured to control a stiffness of the variable stiffness element via a voltage applied to the control element. The pump can also include a controller configured to decrease the stiffness of the variable stiffness element responsive to a high flow rate condition for the pump and/or increase the stiffness of the variable stiffness element responsive to a high pressure condition for the pump. The variable stiffness element can include a thermoplastic material with stiffness controlled by applying heat, an amorphous metal alloy with stiffness controlled by applying a magnetic field, or an electroactive laminate with stiffness controlled by applying an electric field.