Invention Application
- Patent Title: NOVEL POLYPEPTIDES FOR PRODUCING ALBICANOL AND/OR DRIMENOL COMPOUNDS
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Application No.: US17760705Application Date: 2020-11-25
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Publication No.: US20240376502A1Publication Date: 2024-11-14
- Inventor: Qi WANG , Michel SCHALK
- Applicant: FIRMENICH SA
- Applicant Address: CH Satigny
- Assignee: FIRMENICH SA
- Current Assignee: FIRMENICH SA
- Current Assignee Address: CH Satigny
- Priority: WOPCT/CN2019/121244 20191127,EP20153128.2 20200122
- International Application: PCT/EP2020/083408 WO 20201125
- Main IPC: C12P7/22
- IPC: C12P7/22 ; C12N9/14 ; C12P5/00

Abstract:
Described herein are plant-derived haloacid dehalogenase-like (HAD-like) polypeptides having cyclic terpene synthase (TPS) activity, in particular suitable for use in biochemical methods of producing drimane-type sesquiterpenes, encompassing drimenol and/or albicanol and related compounds, like phosphorylated drimane-type sesquiterpene alcohols, in particular phosphorylated drimenol and/or albicanol compounds and derivatives. Also described herein are the coding nucleotide sequences of the TPS activity, corresponding expression constructs, recombinant hosts, and methods of preparing such polypeptides and mutants and variants thereof. Also described herein is a method of using such polypeptides, the method including using the polypeptides in the production of odorants, flavours and fragrance ingredients.
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