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公开(公告)号：US20240287560A1
公开(公告)日：2024-08-29
申请号：US17757752
申请日：2020-12-22
Applicant: FIRMENICH SA
Inventor： Laurent DAVIET , Yang HUANG , Vincent HARRACA , Michel SCHALK , Monica BANDERA
IPC: C12P15/00 , A01N65/08 , A01P7/04 , A61K31/045 , A61K31/11 , A61K36/185 , C11B9/00 , C11B9/02 , C12N9/02 , C12N9/88 , C12P5/00 , C12P7/02
CPC classification number: C12P15/00 , A01N65/08 , A01P7/04 , A61K31/045 , A61K31/11 , A61K36/185 , C11B9/0003 , C11B9/02 , C12N9/0042 , C12N9/0071 , C12N9/88 , C12P5/007 , C12P7/02 , C12Y106/02004 , C12Y402/03082
Abstract: Described herein is a biochemically produced sandalwood oil including at least 85% santalol and bergamotol and 1% or less cis-lanceol, where the oil has one or more of the following features: i) 5% or less alpha-santalal; ii) 5% or less farnesol; and iii) 0.5% or less spirosantalol. Also described herein are a perfuming composition including the sandalwood oil and a perfuming consumer product including the sandalwood oil. Also described herein are a method of using the biochemically produced sandalwood oil as an anti-microbial and anti-inflammatory agent, and an arthropod control composition including the sandalwood oil.
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公开(公告)号：US20190002925A1
公开(公告)日：2019-01-03
申请号：US15737809
申请日：2016-06-30
Applicant: Firmenich SA
Inventor： Michel SCHALK , Letizia ROCCI
CPC classification number: C12P5/002 , C12N9/88 , C12N9/90 , C12N15/63 , C12N15/70 , C12N15/74 , C12N15/79 , C12P5/007 , C12Y402/03 , C12Y505/01012 , C12Y505/01014
Abstract: Provided herein are methods of producing (+)-manool comprising: contacting geranylgeranyl diphosphate with an copalyl diphosphate (CPP) synthase to form a (9S, 10S)-copalyl diphosphate wherein the CPP synthase comprises an amino acid sequence having at least 90%, 95%, 98%, 99% and 100% sequence identity to a polypeptide selected from the group consisting of SEQ ID NO: 1 and SEQ ID NO:2; and contacting the CPP with a sclareol synthase enzyme to form (+)-manool.
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公开(公告)号：US20140162332A1
公开(公告)日：2014-06-12
申请号：US14136938
申请日：2013-12-20
Applicant: FIRMENICH SA
Inventor： Michel SCHALK
IPC: C12P7/02
Abstract: The present invention provides a method of producing sclareol, the method comprising contacting a particular polypeptide having a sclareol synthase activity with labdenediol diphosphate (LPP). In particular, the method may be carried out in vitro or in vivo to produce sclareol, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of the polypeptide used in the method. A nucleic acid derived from Salvia sclarea and encoding the polypeptide of the invention, an expression vector containing the nucleic acid, as well as a non-human organism or a cell transformed to harbor the same nucleic acid, are also part of the present invention.
Abstract translation: 本发明提供了生产香紫苏醇的方法，该方法包括使具有香紫苏醇合成酶活性的特定多肽与二氢二苯酚二磷酸（LPP）接触。 特别地，该方法可以在体外或体内进行以产生香紫苏醇，香料和香料领域中非常有用的化合物。 本发明还提供了该方法中使用的多肽的氨基酸序列。 衍生自丹参的核酸并编码本发明的多肽，含有核酸的表达载体以及转化成含有相同核酸的非人生物体或细胞也是本发明的一部分。
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公开(公告)号：US20170283841A1
公开(公告)日：2017-10-05
申请号：US15619658
申请日：2017-06-12
Applicant: FIRMENICH SA
Inventor： Michel SCHALK , Fabienne DEGUERRY
CPC classification number: C12P15/00 , C12N9/88 , C12N15/8243 , C12P5/002 , C12Y402/0307
Abstract: The present invention provides a method of producing patchoulol and 7-epi-α-selinene, said method comprising contacting at least one polypeptide with farnesyl phyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce patchoulol and 7-epi-α-selinene, compounds which can be useful in the field of perfumery. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing patchoulol and 7-epi-α-selinene is also an object of the present invention.
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公开(公告)号：US20160215301A1
公开(公告)日：2016-07-28
申请号：US15023640
申请日：2014-09-19
Applicant: FIRMENICH SA
Inventor： Laurent DAVIET , Letizia ROCCI , Michel SCHALK
CPC classification number: C12P5/007 , C12N9/0071 , C12N9/0079 , C12P7/02 , C12Y114/13 , C12Y114/14001
Abstract: Methods and compositions for producing a sesquiterpene alcohol comprising contacting a sesquiterpene with a p450 polypeptide with monooxygenase activity.
Abstract translation: 包括用于制备倍半萜醇的方法和组合物，包括使倍半萜烯与单加氧酶活性的p450多肽接触。
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Patent Agency Ranking
公开(公告)号：US20180251797A1
公开(公告)日：2018-09-06
申请号：US15330814
申请日：2015-05-06
Applicant: Firmenich SA
Inventor： Yu-Hua ZHANG , Michel SCHALK , Olivier HAEFLIGER , Xiu-Feng HE , Fabienne DEGUERRY
CPC classification number: C12P7/02 , C12N9/0004 , C12N9/16 , C12P7/04 , C12Y301/07007
Abstract: The present invention relates to a method of producing drimenol and/or drimenol derivatives by contacting at least one polypeptide with farnesyl diphosphate. The method may be performed in vitro or in vivo. The present invention also provides amino acid sequences of polypeptides useful in the method of the invention and nucleic acid encoding the polypeptides of the invention. The method further provides host cells or organisms genetically modified to express the polypeptides of the invention and useful to produce drimenol and/or drimenol derivatives.
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公开(公告)号：US20180105837A1
公开(公告)日：2018-04-19
申请号：US15688956
申请日：2017-08-29
Applicant: Firmenich SA
Inventor： Michel SCHALK
CPC classification number: C12P5/002 , C12N9/88 , C12P5/007 , C12Y402/03083
Abstract: The present invention provides a method of producing β-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce β-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing β-santalene is also an object of the present invention.
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公开(公告)号：US20180094281A1
公开(公告)日：2018-04-05
申请号：US15564671
申请日：2016-04-11
Applicant: Firmenich SA
Inventor： Michel SCHALK , Fabienne DEGUERRY , Pan LI , Xiufeng HE , Qi WANG
CPC classification number: C12P5/007 , C12N9/88 , C12Y402/03039 , C12Y402/03079
Abstract: Provided herein is an isolated polypeptide from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis comprising a (+)-cedrol or a (−)-thujopsene synthase. Further provided herein is an isolated nucleic acid molecule from Juniperus virginiana, Platycladus orientalis ‘Beverleyensis’ or Platycladus orientalis encoding a (+)-cedrol or (−)-thujopsene synthase. Further provided herein are methods of producing (+)-cedrol or (−)-thujopsene.
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公开(公告)号：US20150176029A1
公开(公告)日：2015-06-25
申请号：US14530651
申请日：2014-10-31
Applicant: FIRMENICH SA
Inventor： Michel SCHALK
CPC classification number: C12P5/002 , C12N9/88 , C12P5/007 , C12Y402/03083
Abstract: The present invention provides a method of producing β-santalene, said method comprising contacting at least one polypeptide with farnesyl pyrophosphate (FPP). In particular, said method may be carried out in vitro or in vivo to produce β-santalene, a very useful compound in the fields of perfumery and flavoring. The present invention also provides the amino acid sequence of a polypeptide useful in the method of the invention. A nucleic acid encoding the polypeptide of the invention and an expression vector containing said nucleic acid are also part of the present invention. A non-human host organism or a cell transformed to be used in the method of producing β-santalene is also an object of the present invention.
Abstract translation: 本发明提供了一种生产皂苷的方法，所述方法包括使至少一种多肽与焦亚磷酸法呢基（FPP）接触。 特别地，所述方法可以在体外或体内进行以产生在香料和香料领域中非常有用的化合物。 本发明还提供了可用于本发明方法的多肽的氨基酸序列。 编码本发明多肽的核酸和含有该核酸的表达载体也是本发明的一部分。 非人类宿主生物体或转化用于生产ant al烯的方法的细胞也是本发明的目的。
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公开(公告)号：US20240376502A1
公开(公告)日：2024-11-14
申请号：US17760705
申请日：2020-11-25
Applicant: FIRMENICH SA
Inventor： Qi WANG , Michel SCHALK
Abstract: Described herein are plant-derived haloacid dehalogenase-like (HAD-like) polypeptides having cyclic terpene synthase (TPS) activity, in particular suitable for use in biochemical methods of producing drimane-type sesquiterpenes, encompassing drimenol and/or albicanol and related compounds, like phosphorylated drimane-type sesquiterpene alcohols, in particular phosphorylated drimenol and/or albicanol compounds and derivatives. Also described herein are the coding nucleotide sequences of the TPS activity, corresponding expression constructs, recombinant hosts, and methods of preparing such polypeptides and mutants and variants thereof. Also described herein is a method of using such polypeptides, the method including using the polypeptides in the production of odorants, flavours and fragrance ingredients.
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