Alkaline cleaning compositions using a detersive combination of surfactants, chelants and enzymes with reduced alkalinity, including between about 20-47% by percent Na2O in the liquid or solid compositions, are disclosed. Methods of using the compositions with optimal protein removal performance that overcome limitations of reduced alkalinity content for use in cleaning, rinsing, sanitizing, and disinfecting are disclosed along with methods that stabilize enzymes for multi-cycle dispensing in solid compositions.