Invention Application
- Patent Title: CANNABINOID-LIPID CONJUGATES, METHODS FOR PRODUCING THE SAME AND USES THEREOF
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Application No.: US18694614Application Date: 2022-09-22
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Publication No.: US20240398839A1Publication Date: 2024-12-05
- Inventor: Daniel OFFEN , Nataly YOM-TOV
- Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Applicant Address: IL Tel Aviv
- Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Current Assignee: RAMOT AT TEL-AVIV UNIVERSITY LTD.
- Current Assignee Address: IL Tel Aviv
- Priority: IL286604 20210922
- International Application: PCT/IL2022/051012 WO 20220922
- Main IPC: A61K31/00
- IPC: A61K31/00 ; A61K47/54

Abstract:
Provided is a cannabinoid-phospholipid conjugate where the cannabinoid is covalently linked, via a cleavable linker, to a polar head group of the phospholipid. Also provided is a method of obtaining the conjugate, the method comprising (a) reacting the phospholipid (PL) dissolved in an organic solvent with maleic anhydride (MA) to obtain PL-MA intermediate; and (b) reacting said PL-MA intermediate with the cannabinoid in the presence of a carboxyl activating agent and an esterification agent to obtain a reaction mixture comprising said conjugate. Uses of the conjugate are also disclosed.
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