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公开(公告)号:US20230112169A1
公开(公告)日:2023-04-13
申请号:US17913544
申请日:2021-03-22
发明人: Yael BEKERMAN , Shai AVIDAN , Tali TREIBITZ
摘要: A method of estimating attenuation coefficient ratios from digital image acquired in a scattering medium is disclosed. The method may include, receiving a digital image acquired in a scattering medium; and estimating the attenuation coefficient ratios directly from the digital image. Further is disclosed a method of estimating veiling light values. The method may include receiving a digital image acquired in a scattering medium; and estimating the veiling light value directly from pixels in the digital image associated with objects.
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公开(公告)号:US20230065065A1
公开(公告)日:2023-03-02
申请号:US17975214
申请日:2022-10-27
IPC分类号: C07D409/12 , A61P25/28 , C07D487/08
摘要: Compounds represented by general Formulae I to IV as described herein are disclosed. Further disclosed are composition utilizing the herein disclosed compounds and using the same for the treatment of glycogen storage disorders.
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公开(公告)号:US20230058044A1
公开(公告)日:2023-02-23
申请号:US17779704
申请日:2020-11-25
发明人: Vered PADLER-KARAVANI , Yafit ATIYA-NASAGI , Ron AMON , Anat GLOBERSON LEVIN , Tova WAKS , Moran RAWET-SLOBODKIN , Lihi NINIO MANY , Zelig ESHHAR
IPC分类号: A61K35/17 , C07K14/725 , C07K14/705 , C07K14/735 , C12N5/0783
摘要: The present invention discloses chimeric antigen receptors that specifically recognize and bind to SLe A carbohydrate antigen with high specificity and selectivity. The invention further provides lymphocytic cells, such as T cells, comprising said CARs, compositions comprising said cells or CARs as well as uses thereof.
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公开(公告)号:US20230053258A1
公开(公告)日:2023-02-16
申请号:US17793943
申请日:2020-12-10
发明人: Itai BENHAR , Limor NAHARY , Dan FRENKEL , Ofir FURSHT , Yuval NASH , Mirit LIRAN
IPC分类号: C07K16/40 , G01N33/68 , G01N33/564 , A61P25/28
摘要: Isolated anti-IDE antibodies are provided. Each of the antibodies comprise an antigen recognition domain comprising the indicated CDR amino acid sequences. Methods of producing same, methods of using same, pharmaceutical compositions comprising same and articles of manufacture are also provided.
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公开(公告)号:US20230026620A1
公开(公告)日:2023-01-26
申请号:US17779355
申请日:2020-11-25
IPC分类号: C12N15/82 , C07K14/415
摘要: The present invention relates to plants, particularly to crop plants including plants of the family Solanaceae having reduced expression and/or activity of Sl ROP9 protein or homologs thereof, displaying increased water use efficiency (WUE) and enhanced tolerance to drought and/or salt stress, with minimal effect on the crop yield.
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公开(公告)号:US11531902B2
公开(公告)日:2022-12-20
申请号:US16189744
申请日:2018-11-13
申请人: International Business Machines Corporation , Trustees of Tufts College , Ramot at Tel-Aviv University Ltd.
发明人: Lior Horesh , Elizabeth Newman , Misha E. Kilmer , Haim Avron
摘要: Techniques for generating and managing, including simulating and training, deep tensor neural networks are presented. A deep tensor neural network comprises a graph of nodes connected via weighted edges. A network management component (NMC) extracts features from tensor-formatted input data based on tensor-formatted parameters. NMC evolves tensor-formatted input data based on a defined tensor-tensor layer evolution rule, the network generating output data based on evolution of the tensor-formatted input data. The network is activated by non-linear activation functions, wherein the weighted edges and non-linear activation functions operate, based on tensor-tensor functions, to evolve tensor-formatted input data. NMC trains the network based on tensor-formatted training data, comparing output training data output from the network to simulated output data, based on a defined loss function, to determine an update. NMC updates the network, including weight and bias parameters, based on the update, by application of tensor-tensor operations.
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公开(公告)号:US20220396801A1
公开(公告)日:2022-12-15
申请号:US17870607
申请日:2022-07-21
申请人: B. G. NEGEV TECHNOLOGIES AND APPLICATIONS LTD., AT BEN-GURION UNIVERSITY , RAMOT AT TEL-AVIV UNIVERSITY LTD
发明人: Tamir TULLER , Michael PEERI , Yonatan CHEMLA , Lital ALFONTA
IPC分类号: C12N15/67
摘要: Nucleic acid molecule and vectors comprising regions of high or low folding energy are provided. Methods of producing coding sequences optimized for protein expression comprising introducing a mutation that increases or decreased folding energy are also provided.
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8.
公开(公告)号:US20220372621A1
公开(公告)日:2022-11-24
申请号:US17305206
申请日:2021-07-01
申请人: MELLANOX TECHNOLOGIES, LTD. , BAR-ILAN UNIVERSITY , RAMOT AT TEL-AVIV UNIVERSITY LTD. , SIMTAL NANO-COATINGS LTD
发明人: Elad MENTOVICH , Yaniv ROTEM , Yaakov GRIDISH , Doron NAVEH , Chen STERN , Yosi BEN-NAIM , Ariel ISMACH , Eran BAR-RABI , Tal KAUFMAN
IPC分类号: C23C16/458
摘要: A substrate carrier and a mechanism for moving the substrate carrier through a chemical vapor deposition system are provided. The substrate carrier includes a cylindrical housing having an interior surface. A plurality of plurality of shelves fixed to the interior surface, each shelf configured to support at least one substrate. The substrate carrier may include a connector configured to engage the substrate carrier with the mechanism. The mechanism may include a moveable arm and a motor configured to actuate the moveable arm. The moveable arm may include an actuating member connected to the motor and configured to move the moveable arm between a retracted state and an extended state. The moveable arm may be configured to operate in a chamber having a first pressure and a first temperature and the motor may be configured to operate in an environment having a second pressure.
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公开(公告)号:US20220306710A1
公开(公告)日:2022-09-29
申请号:US17748212
申请日:2022-05-19
发明人: Ruth ARNON , Ruth MARON , Gad ARMONY , Michael Menachem TSOORY , Meir WILCHEK , Dan FRENKEL
摘要: A method of treating Alzheimer's Disease (AD) is disclosed. The method comprises administering to the subject a therapeutically effective amount of an agent which prevents the binding of amyloid precursor protein (APP) to Tau protein.
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公开(公告)号:US11452998B2
公开(公告)日:2022-09-27
申请号:US16076365
申请日:2017-02-08
发明人: Moshe Kol , Tomer Rosen , Yanay Popowski
IPC分类号: C07D213/36 , B01J31/22 , C08G63/82 , C07D401/14
摘要: A new family of mononuclear organometallic complexes of a divalent metal bound to sequential tetradentate monoanionic {ONNN}-type ligands, and polymerization of cyclic esters such as lactides utilizing same are provided. Novel tetradentate monoanionic {ONNN}-type ligands usable for forming these complexes are also provided.
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