Invention Application
- Patent Title: PEPTIDE MODULATORS OF NEUROLIGIN 4-NEUREXIN 1-BETA AXIS FOR TREATMENT OF LIVER DISORDERS
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Application No.: US18812184Application Date: 2024-08-22
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Publication No.: US20240409602A1Publication Date: 2024-12-12
- Inventor: Rifaat SAFADI , Johnny AMER
- Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
- Applicant Address: IL Jerusalem
- Assignee: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
- Current Assignee: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.
- Current Assignee Address: IL Jerusalem
- Main IPC: C07K14/705
- IPC: C07K14/705 ; A61K35/17 ; A61K38/00 ; A61P1/16 ; A61P35/00 ; C12N5/0783
Abstract:
Provided herein are isolated peptides capable of affecting neuroligin-4 (NLGn4)-neurexin 1β (Nrx1β) protein-protein interaction and interfering with NLGn4X/Nrx1β axis between Hepatic Stellate Cells (HSCs) and Natural killer (NK). Further provided are compositions including such peptides and uses thereof for treating and/or attenuating liver-related conditions and various types of cancer.
Information query
