公开(公告)号：US20240409602A1

公开(公告)日：2024-12-12

申请号：US18812184

申请日：2024-08-22

Applicant: HADASIT MEDICAL RESEARCH SERVICES AND DEVELOPMENT LTD.

Inventor： Rifaat SAFADI ,  Johnny AMER

IPC: C07K14/705 ,  A61K35/17 ,  A61K38/00 ,  A61P1/16 ,  A61P35/00 ,  C12N5/0783

Abstract: Provided herein are isolated peptides capable of affecting neuroligin-4 (NLGn4)-neurexin 1β (Nrx1β) protein-protein interaction and interfering with NLGn4X/Nrx1β axis between Hepatic Stellate Cells (HSCs) and Natural killer (NK). Further provided are compositions including such peptides and uses thereof for treating and/or attenuating liver-related conditions and various types of cancer.