Techniques are described herein for network slice availability based de-prioritization. An example, method includes receiving user equipment (UE) routing selection policy (URSP) information. The method further includes starting an application associated with a network slice while registered with a standalone (SA) network. The method further includes evaluating routing selection descriptor information in the URSP information to determine an availability of the network slice of the SA network. The method further includes determining whether to de-prioritize the SA network based on a determination of availability of the network slice as indicated by the routing selection descriptor information.