Provided is a biosensor. The biosensor includes: a base substrate; a plurality of detection units disposed on a side of the base substrate, wherein each of the plurality of detection units includes a gate; a first drive signal line disposed on the side of the base substrate and electrically connected to the gate; and a cover plate fixedly connected to the side of the base substrate, wherein a plurality of recesses are defined in a side, proximal to the base substrate, of the cover plate.