发明授权
US3557162A Process for the preparation of 17alpha-monoesters of 11beta,17alpha,21-trihydroxysteroids
失效
制备11BETA,17ALPHA,21-TRIHYDROXYSTEROIDS的17ALPHA-MONOESTERS的方法
- 专利标题: Process for the preparation of 17alpha-monoesters of 11beta,17alpha,21-trihydroxysteroids
- 专利标题(中): 制备11BETA,17ALPHA,21-TRIHYDROXYSTEROIDS的17ALPHA-MONOESTERS的方法
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申请号: US3557162D申请日: 1969-01-23
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公开(公告)号: US3557162A公开(公告)日: 1971-01-19
- 发明人: LENS JAN , MARX ARTHUR F
- 申请人: KONINKLIJKE GIST SPIRITUS
- 专利权人: Koninklijke Gist Spiritus
- 当前专利权人: Koninklijke Gist Spiritus
- 优先权: GB358768 1968-01-23
- 主分类号: A61K31/565
- IPC分类号: A61K31/565 ; A61K31/573 ; C07J5/00 ; F21V17/20 ; C07C167/28
摘要:
17A-MONOESTERS OF 11B,17A,21-TRIHYDROXYSTEROIDS ARE PREPARED BY SILYLATING THE 11B-HYDROXYL GROUP OF AN 11B, 17A-DIHYDROXY-21-ACLOXY STEROID TO A SILYLOXY GROUP, ESTERIFYING THE 17A-HYDROXYL GROUP, AND THEN REMOVING THE SILYL GROUP AT THE 11B POSITION AND THE ACYL GROUP AT THE 21 POSITION BY HUDROLYSIS OR ALCOHOLYSIS.