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公开(公告)号:US3678082A
公开(公告)日:1972-07-18
申请号:US3678082D
申请日:1970-07-30
申请人: SEARLE & CO
发明人: DRYDEN HUGH L JR
IPC分类号: C07C167/28
CPC分类号: C07J1/00
摘要: 17-Hydroxy steroids can be esterified in nearly quantitative yields using the appropriate anhydride with 4dimethylaminopyridine.
摘要翻译: 可以使用合适的酸酐与4-二甲基氨基吡啶,以几乎定量的收率酯化17-羟基类固醇。
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2.Process for the acylation of 17{62 -hydroxysteroids containing an enolizable oxo-group 失效
标题翻译: 17种含有可氧化氧化物的62-羟基甾醇化合物的方法公开(公告)号:US3761496A
公开(公告)日:1973-09-25
申请号:US3761496D
申请日:1971-07-06
发明人: TUBA Z , BOR NEE SZABO M , MOLNAR K , GOROG S
IPC分类号: A61K20060101 , C07C20060101 , C07J1/00 , C07C167/28
CPC分类号: C07J75/00
摘要: This invention relates to the acylation of 17 Beta hydroxysteroids containing an enolizable oxogroup in the A-ring having the general formula I
wherein X represents a straight-chain, branched-chain or cyclic acyl group of one to eight carbon atoms or a haloacyl group of one to three carbon atoms, Y represents ethynyl, vinyl, allyl group or an alkyl group of one to four carbon atoms, and Z represents hydrogen group or methyl.摘要翻译: 本发明涉及在具有通式I的A环中含有可烯化氧基团的17个β-羟基类固醇的酰化,其中X代表1-8个碳原子的直链,支链或环状酰基或卤代酰基 1至3个碳原子,Y表示乙炔基,乙烯基,烯丙基或1-4个碳原子的烷基,Z表示氢基或甲基。
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3.Process for the preparation of 17alpha-monoesters of 11beta,17alpha,21-trihydroxysteroids 失效
标题翻译: 制备11BETA,17ALPHA,21-TRIHYDROXYSTEROIDS的17ALPHA-MONOESTERS的方法公开(公告)号:US3557162A
公开(公告)日:1971-01-19
申请号:US3557162D
申请日:1969-01-23
发明人: LENS JAN , MARX ARTHUR F
IPC分类号: A61K31/565 , A61K31/573 , C07J5/00 , F21V17/20 , C07C167/28
CPC分类号: A61K31/573 , A61K31/565 , C07J5/00 , F21V17/20
摘要: 17A-MONOESTERS OF 11B,17A,21-TRIHYDROXYSTEROIDS ARE PREPARED BY SILYLATING THE 11B-HYDROXYL GROUP OF AN 11B, 17A-DIHYDROXY-21-ACLOXY STEROID TO A SILYLOXY GROUP, ESTERIFYING THE 17A-HYDROXYL GROUP, AND THEN REMOVING THE SILYL GROUP AT THE 11B POSITION AND THE ACYL GROUP AT THE 21 POSITION BY HUDROLYSIS OR ALCOHOLYSIS.
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4.Bicyclo(2.2.2)octane - 1-carboxylate carbonate esters of estrogenic steroids 失效
标题翻译: BICYCLO(2.2.2)月桂酸酯 - 1-羧酸异丁酯的碳酸酯酯公开(公告)号:US3484465A
公开(公告)日:1969-12-16
申请号:US3484465D
申请日:1967-09-07
申请人: SYNTEX CORP
发明人: CROSS ALEXANDER D , FRIED JOHN H
IPC分类号: A61K31/567 , A61K31/57 , C07J1/00 , C07J51/00 , C07C169/36 , A61K17/00 , C07C167/28
CPC分类号: A61K31/567 , A61K31/57 , C07J1/00 , C07J51/00
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5.Water-soluble corticoid compounds that decompose in plasma or tissue fluid with liberation of a free corticoid;and process of producing said compounds 失效
标题翻译: 可溶解的等离子体化学组合物,可溶于无水正丁醇的等离子体或组织液;以及生产化合物的方法公开(公告)号:US3513177A
公开(公告)日:1970-05-19
申请号:US3513177D
申请日:1966-04-06
IPC分类号: A61K31/573 , C07J5/00 , C07J19/00 , C07J75/00 , C07C167/28
CPC分类号: A61K31/573 , C07J5/00 , C07J19/00 , C07J75/00
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公开(公告)号:US3493589A
公开(公告)日:1970-02-03
申请号:US3493589D
申请日:1966-11-17
申请人: AMERICAN HOME PROD
发明人: JEN TIMOTHY Y W
IPC分类号: C07J1/00 , C07J75/00 , C07C169/12 , A61K17/06 , C07C167/28
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7.Bicyclo(2.2.2)octane-1-carboxylate esters of progestational steroids 失效
标题翻译: BICYCLO(2.2.2)孕激素替代物的1-羧酸酯公开(公告)号:US3485853A
公开(公告)日:1969-12-23
申请号:US3485853D
申请日:1967-09-07
申请人: SYNTEX CORP
发明人: CROSS ALEXANDER , FRIED JOHN H
IPC分类号: C07J5/00 , C07J75/00 , C07C169/36 , C07C167/28 , C07C173/00
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公开(公告)号:US3483234A
公开(公告)日:1969-12-09
申请号:US3483234D
申请日:1966-10-17
申请人: SEARLE & CO
发明人: KLIMSTRA PAUL D
IPC分类号: C07C169/24 , A61K27/00 , C07C167/28
CPC分类号: C07J1/00
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9.Process for selectively acylating the 3-ol group in polyhydroxy 13-alkyl gona-(and 8 - isogona) - 1,3,5 - (10) - trienes and delta - 7 -,delta - 8(9),delta - 9(11) -,and delta - 8(9),14(15) - dehydro derivatives thereof 失效
标题翻译: 选择性地处理多羟基13-烷基GONA-(和8-异丙基)1,3,5 - (10) - 三烯和三 - 七 - ,十 - 八(9),三 - 9 (11) - ,和DELTA-8(9),14(15) - 其衍生物公开(公告)号:US3478070A
公开(公告)日:1969-11-11
申请号:US3478070D
申请日:1967-12-26
申请人: AMERICAN HOME PROD
发明人: STEIN REINHARDT P , SMITH HERCHEL
IPC分类号: C07J1/00 , C07J75/00 , C07C167/28 , A61K27/00 , C07C169/08
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10.
公开(公告)号:US3468918A
公开(公告)日:1969-09-23
申请号:US3468918D
申请日:1966-12-05
申请人: HOECHST AG
IPC分类号: C07J5/00 , C07J75/00 , C07C167/28 , C07C167/14 , C07C169/36
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