A resilient static and dynamic sealing assembly for maintaining a fluidtight joint or connection between operatively associated elements where the elements are made of materials having different coefficients of expansion and one element of a relatively stronger material acts to confine the other material in the operative position. The sealing assembly includes on the confined element an elastomeric means which coacts with an annular wall in engagement with the confining element and acts with the annular wall to maintain the seal within conventionally anticipated temperature ranges at least between 32* and 212* F. The sealing assembly can be provided with means for adjusting the force exerted to form the seal between the operatively associated elements. Further, the sealing assembly will provide an improved laboratory Burette, disposable hypodermic syringes and other devices adapted to utilize the same.