发明授权
- 专利标题： Derivatives of 4-hydroxy coumarin and the preparation thereof
- 专利标题（中）： 4-羟基甘氨酸的衍生物及其制备方法
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申请号： US3651091D申请日： 1969-11-21
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公开(公告)号： US3651091A公开(公告)日： 1972-03-21
- 发明人: BOSCHETTI EUGENE , MOLHO DARIUS , FONTAINE LOUIS
- 申请人： LIPHA
- 专利权人： Merck Sante SAS
- 当前专利权人： Merck Sante SAS
- 优先权： FR87213 1966-12-13; FR127915 1967-11-13; FR175753 1968-11-28
- 主分类号： C07D311/12
- IPC分类号： C07D311/12 ; A01N43/16 ; A61K31/37 ; C07D311/42 ; C07D409/06 ; E04G21/26 ; C07D7/30
摘要：
THE 4-HYDROXY COUMARINS ARE REPRESENTED BY THE FORMULA
2-(O=),3-(R1-CH(-OH)-CH2-CH(-R)-),4-(HO-),R2-2H-CHROMENE
IN WHICH R IS A MEMBER OF THE GROUP FORMED BY HYDROGEN, THE PHENYL, HALOPHENYL, HIHALOPHENYL, NITROPHENYL, METHOXPENYL, TOLYL, METHYLENE DIOXPHENYL AND FURYL RADICALS; R1 IS A MEMBER OF THE GROUP FORMED BY THE METHYL, PHENYL, HALOPHENYL, NITROPHENYL, DIPHENYL, HALODIPHENYL, NITRODIPHENYL AND NAPHTHYL RADICALS; AND R2 IS HYDROGEN OR A HALOGEN. THESE ARE 4-HYDROXY COUMARINS HAVE VERY POWERFUL ORAL ANTICOAGULATING ACTIONS OF THE ANTIVITAMIN K TYPE.
2-(O=),3-(R1-CH(-OH)-CH2-CH(-R)-),4-(HO-),R2-2H-CHROMENE
IN WHICH R IS A MEMBER OF THE GROUP FORMED BY HYDROGEN, THE PHENYL, HALOPHENYL, HIHALOPHENYL, NITROPHENYL, METHOXPENYL, TOLYL, METHYLENE DIOXPHENYL AND FURYL RADICALS; R1 IS A MEMBER OF THE GROUP FORMED BY THE METHYL, PHENYL, HALOPHENYL, NITROPHENYL, DIPHENYL, HALODIPHENYL, NITRODIPHENYL AND NAPHTHYL RADICALS; AND R2 IS HYDROGEN OR A HALOGEN. THESE ARE 4-HYDROXY COUMARINS HAVE VERY POWERFUL ORAL ANTICOAGULATING ACTIONS OF THE ANTIVITAMIN K TYPE.
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