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    COUMARIN DERIVATIVE
    6.
    发明申请
    COUMARIN DERIVATIVE 有权
    COUMARIN衍生物

    公开(公告)号：US20150232440A1

    公开(公告)日：2015-08-20

    申请号：US14429300

    申请日：2013-09-20

    申请人： NIPPON ZOKI PHARMACEUTICAL CO., LTD.

    发明人： Mitsuru Naiki ,  Tomoyuki Okada ,  Kazuyoshi Sawada ,  Takashi Ogino

    IPC分类号： C07D311/12

    CPC分类号： C07D311/12 ,  A61K31/352 ,  C07D311/18 ,  C07D405/12 ,  C07D409/12

    摘要： A novel coumarin derivative or a pharmaceutically acceptable salt thereof and also to provide a pharmaceutical agent containing such a compound as an active ingredient is provided. The coumarin derivative or a pharmaceutically acceptable salt thereof exhibits an excellent suppressive action to the destruction of cartilage and suppressive action to the proliferation of synovial cells in a pharmacological test where the release of sulfated glycosaminoglycans (sGAG) and the proliferation of synovial cells are used as indicators whereby it is very useful as an active ingredient of a pharmaceutical composition such as a preventive or therapeutic agent for arthropathy such as osteoarthritis or chronic rheumatoid arthritis.

    摘要翻译： 提供了一种新型香豆素衍生物或其药学上可接受的盐，并且还提供含有这种化合物作为活性成分的药剂。 香豆素衍生物或其药学上可接受的盐在药理学试验中对软骨破坏和对滑膜细胞增殖的抑制作用显示出优异的抑制作用，其中硫酸化糖胺聚糖（sGAG）的释放和滑膜细胞的增殖被用作 指标，其作为药物组合物的有效成分非常有用，例如关节病如骨关节炎或慢性类风湿性关节炎的预防或治疗剂。

    CHEMICAL ENHANCEMENT BY NANOMATERIALS UNDER X-RAY IRRADIATION
    7.
    发明申请
    CHEMICAL ENHANCEMENT BY NANOMATERIALS UNDER X-RAY IRRADIATION 有权
    通过X射线辐射下的纳米材料的化学增强

    公开(公告)号：US20140371471A1

    公开(公告)日：2014-12-18

    申请号：US14370733

    申请日：2013-01-11

    申请人： The Regents of the University California

    发明人： Ting Guo

    IPC分类号： C07D311/12

    CPC分类号： C07D311/12

    摘要： A method for dynamic enhancement of chemical reactions by nanomaterials under hard X-ray irradiation. The nanomaterials were gold and platinum nanoparticles, and the chemical reaction employed was the hydroxylation of coumarin carboxylic acid. The reaction yield was enhanced 2000 times over that predicted on the basis of the absorption of X-rays only by the nanoparticles, and the enhancement was found for the first time to depend on the X-ray dose rate. The maximum turnover frequency was measured at 116×10-4 s-1 Gy-1. We call this process chemical enhancement, which is defined as the increased yield of a chemical reaction due to the chemical properties of the added materials. The chemical enhancement described here is believed to be ubiquitous and may significantly alter the outcome of chemical reactions under X-ray irradiation with the assistance of nanomaterials.

    摘要翻译： 一种在硬X射线照射下由纳米材料动态增强化学反应的方法。 纳米材料是金和铂纳米颗粒，所用的化学反应是香豆素羧酸的羟基化。 基于仅通过纳米颗粒吸收X射线而预测的反应产率增加了2000倍，并且首次发现增强取决于X射线剂量率。 最大周转频率为116×10-4 s-1 Gy-1。 我们称这种过程化学增强，其定义为由于所添加的材料的化学性质引起的化学反应的增加的产率。 这里描述的化学增强被认为是普遍存在的，并且可以在纳米材料的帮助下在X射线照射下显着改变化学反应的结果。