THE DISCLOSURE IS DIRECTED TO A PROCESS OF ENZYMATICALLY CONVERTING A PORTION OF THE GLUCOSE IN A GLUCOSE-CONTAINING SOLUTION TO FRUCTOSE. VIABLE MICROORGANISM WHICH CONTAIN INTRACELLULAR GLUCOSE ISOMERASE ARE TREATED WITH A TOXIC AGENT OT DESTROY AT LEAST 95 PERCENT OF THE MICROORGANISMS. THE TREATED MICROORGANISM ARE CULTURED TO PROMOTE GROWTH, AND THE CELLULAR MATERIAL THEREFROM IS INCORPORATED INTO A GLUCOSE SOLUTION WHEREIN CONDITIONS ARE MAINTAINED TO CONVERT A PORTION OF THE GLUCOSE TO FRUCTOSE.